[gentle atmospheric music]
-[Francesca] Oh, come on!
Oi! This isn't fair!
Not fair! Not fair!
[laughter and squealing]
[squealing]
[gentle atmospheric music]
[alarm sounds]
- [Dom] Go, go, go! Come on, everyone, you know what to do.
Go! Let's go!
Stop. This is serious.
Archie!
[alarm continues] Move.
Nice and steady. Archie, you know what to do.
- Yup - Quick as you can.
Come on, Tillie. Sage, that's it. You're safe.
Archie, backpacks, fast.
Come on. Quick as you can. Quick as you can.
[alarm continues]
- [Dom] Quickly, quickly. Come on, guys. - [Francesca] For your sister.
Tillie, here you go. Tillie.
- [Dom] Just go, just go, just go. - [Archie] Mum!
-[Dom] Keep close behind me. That's it.
Keep the pace up, guys. Keep the pace up.
Move ahead. Come on move ahead.
Keep going. Quick, quick, quick.
[Archie] Come on.
[Dom] That's it. Bags in the boot.
Here you go, darling. Off you go.
Good girl.
Two minutes, 20.
Sloppy work, people. Sloppy work.
We should be able to do it in under two.
[zipper creaks, tablets rattle]
[solemn music]
[newsreader] Relief for tens of thousands of city residents this morning
as predicted storms fall well to the west of the city.
Not such good news, I'm afraid, for the people of Oberon and Wisemans Creek.
Winds topping 170km/hr raged through the night.
Some Pacific island nations were also unlucky,
bearing the full force of Hurricane Katelyn,
with multiple casualties and some isolated islands completely devastated.
[electronic beep, broadcast ends]
Are you sure you can't start tomorrow?
-[Eadie] It's National Service.
I don't remember them saying
"Turn up when you feel like it" on the form.
I just don't understand why you don't get Dom to sort you out an exemption.
[Eadie] I don't understand why I have so many shoes. I mean, it's absurd.
Is there some sort of weird thing going on between you and him?
You don't want him to do you a favour or something?
It's like I've got some sort of octopus delusion or something.
I mean, how many feet do I really think I have?
And are you sure you can't start tomorrow?
I don't want an exemption, alright. I don't want to be exempt.
I just want to do something that's not about me for one second, and you're...
I don't know why you're so hung up about it. Why do you even care?
Is that... Have you got product in your hair?
No. Ye... Maybe.
Oh, shit.
Oh, shit. Shit! I'm so sorry.
- You're presenting today. - Yeah. Yeah, we are.
- I'm so sorry. - It's OK. It's fine.
It's not a big deal. It's...
Of course it's a big deal.
It's the biggest presentation of your career.
- Don't worry about it. It's fine. - I'm gonna call them.
- I'll see if I can... - Don't. Just...
[scoffs] I'm such a bad wife. I'm sorry. I just...
I'm so sorry.
I'm just a bit all over the shop at the moment.
Hey, hey.
It's okay.
You go do your thing.
If you don't show up when we win the Nobel Prize,
then we've got a real problem, OK?
[quietly] I love you, baby.
[quietly] I love you too.
[tender orchestral music]
[bus engine idling]
[indistinct radio chatter]
[beep]
[electronic voice] Please repeat after me - In Australia, my voice identifies me.
What if I don't want to?
[ai assist] Please repeat after me - In Australia, my voice identifies me.
[Australian accent] "In Australia, my voice identifies me."
[beep]
[haunting atmospheric music]
[crowd chatter, indistinct announcements]
[muffled announcement]
[man] Get your bags ready please. Passports...
[haunting atmospheric music]
- [man] If you're only here for emergency relief,
but you're planning to return to your homes,
please make your way back to the pavilion.
Now, if you're here applying for an Urban Residency Permit,
you need to go through the registration tent
and get an identity wristband.
[haunting atmospheric music]
[muffled shouting]
[man] Good morning National Service.
Correct? You're the new National Service person?
- Yeah. - Awesome.
Eadie. Abel Keralo. Get gloved up, masked up.
We don't get on top of this intake, the whole day is shot.
Everyone gets a blood test for hepatitis,
HIV, malaria, Ross River, yellow fever, typhoid.
Swabs in there for influenza.
Blood smear for chagas. Skin test for TB.
And they spit in a cup on the way out.
What's the spit for?
DNA repository.
Wow. They have a choice?
Or - you want help, you hand over the data?
I'm sorry, you are a doctor, right?
'Cause they told me I was getting a doctor.
Yeah, I'm a neuropsychologist.
[chuckles]
Oh, great.
As they say in medical terms,
I need someone who can put 300 sausages on buns
and they send me a souffle chef.
[exasperated sigh]
[PA announcement] Attention, attention.
[muffled PA announcement]
[Abel] Ta.
[speaker feedback]
Hi. Attention, everyone.
You all need to get your wristbands scanned.
If you were given a positive medical score,
you'll be shown how to access food and clothing and shown where to sleep.
Now, if you have a negative medical score,
you'll be led through the side doors,
where Border Control Officers will direct you onto the buses.
Thank you.
[crowd chatter, muffled announcements]
So what happens to the people who end up back on the bus?
They go back to their residency zone,
treated in hospitals close to their registered address.
Back to the rural hospitals?
That don't have the expertise to treat what they've got in the first place.
The centre's remit is to help those who qualify for it.
Remit?
Welcome to the remit.
[solemn music]
- Hey. - Hey.
Stonehewen.
Concierge. I buzz you through to see your brother.
Yeah, sorry, I didn't...
Recognise me without the suit.
Yeah. [laughs]
Do you do the security here as well?
No, no. Um... my family are here.
They still had to do their regional year
before they could apply to come into the city.
Do you work here?
No, I'm a volunteer. National Service. Just helping out in the medical tents.
Oh, well, you drew the short straw.
Cool. I won't hold you.
- Hey. - Hey.
Give us your phone.
I've gotta show you how this data loop works.
So...
This is a loop of last week's data when you, ah...
lost the baby.
This will keep coming to you and Lloyd in a loop until you take the implant off.
And this is what's actually going on inside there.
Thank you.
Eadie, are you sure you shouldn't just tell him now?
Tell him.
Ask forgiveness.
I think I've missed that boat.
Right now, until I know if this one's sticking around,
the only reason to tell him is so I'd feel better.
OK.
Good luck for today.
[chattering]
[electronic beeps, phones ringing]
Great.
All good?
- [announcer] The presentation will begin...
-You sent me your key data, yeah?
[beep]
Just released by the legal team.
All methodology specifications
have been registered this morning as proprietary knowledge.
But you have to stick absolutely on script.
Yes, you mentioned, Herman. Twelve times.
You deviate and include any more of the data,
we're going to have to give it away for free.
- I get it. - Do you?
Just a reminder, there's 300 campuses,
12 venture capitalists with declared interests
just waiting for you to slip up
and give them just enough to make their own running without us.
- I get it, OK. I get it! - OK.
[tense music]
Lloyd.
Thank you.
[chattering]
[bike horn beeps]
Oh, shit. Look out.
[male newsreader] Scientists gathered today for a major announcement
at the National Institute of Science...
[female newsreader] Two young vector biologists...
[female newsreader two] The fight against chagas disease
has taken on a new urgency...
Excuse me, can I get through, please? Thank you.
With rising temperatures delivering an explosion in populations
- of the kissing bug... - [Shay] Excuse me. Sorry...
which carry this deadly disease.
Early peer review of the pair's materials has sounded positive notes.
But, as ever, it's not until the full data set is revealed
that the real importance of this work can be evaluated.
[chattering]
Sorry, can I just...
- Mate... - Sorry, I didn't set my alarm.
[man] Shay.
- You are not wearing that. - What?
[Lloyd sighs]
What?
Oh, sausage, are you nervous?
Please don't. Don't, OK? Not today, OK?
[announcement chime]
[announcer] The presentation will begin in...
- This is why I forgot to set my alarm. - [announcer]...doors will close...
I kept on having visions of this mob shooting the whole thing down.
All the things that we missed.
Yeah. Finally and completely being exposed as faking it.
- Faking it? - Me, darling, not you.
- You never fake it. - Don't touch me. OK.
-[technician] Hey. Mics are on now.
In searching for a high efficiency gene disruption in Trypanosoma Cruzi,
the etiologic agent of chagas disease,
we had a singular hypothesis.
This shows the C-terminal tagging of the endogenous proteins...
We used the... [voice fades]
Cas9/pTREX vector
to insert...
[Shay]... SGRJ targeted the GO1 is
PCR amplified and cloned.
The donor sequence contains both the tag sequence and the marker
for antibiotic resistance...
in addition to more than 100bp homology arms corresponding
to regions located upstream
of the stop codon and downstream of the Cas9 target site.
- [Lloyd] ..aiming to induce a double strand break in a site
that could be replicated multiple times down the germ line.
And verify that it doesn't generate off target effects
on the T.cruzi genome...
And so we come to the final results and to the sigma.
What's the "sigma"?
Oh, it's the number that lets us know if your dad's results were a fluke or not.
So, zero - obvious fail.
Two's good. Three's excellent.
All the way up to four, out of the park.
It's yours.
Take it.
[energetic strings begin to fade in]
Detached flagella indicated by the white arrows.
Single cell details shown in Panel 'B'.
Second generation blood count... numbers are in green.
And when we run these numbers through our standard deviation modelling...
it delivers a sigma of... five.
[applause]
[tense atmospheric music]
[cheering]
[applause continues]
[cameras click]
If there was ever a reason to take a day off...
I know, I would love to, but I have a tonne of work to do.
And I'd rather take the day off with you when we can just hang out together, OK.
Come on, I'll take you. You'll be back in time for maths.
Hey, thank you.
Thank you for bringing her down.
Couldn't be happier for you.
Interview requests
from SCN, ASR,
Stream 365 News and CBN.
Three companies are offering us equipment.
And an offer to fly us to the Capstone Festival in Prague next week.
[chuckles] OK.
Here we go.
Remarkable. Who'd have thought it?
Certainly not you, Herm.
Judgements I retract in full.
I mean, I could go on about it but I'd rather make good in kind.
What's that?
Preliminary research budget.
But get ready for some serious courting.
There are a dozen expressions of interest already.
How many years is this over?
Oh, ah, just the one.
Better make a plan for spending it before the board changes their mind.
[Shay chuckles]
Today's been a good day, eh?
Yeah, it has indeed.
No Eadie?
No, no, she's made the National Service commitment.
She wanted to bail but I insisted.
Zahra Malak, CBM News.
I'm wondering if you can talk about
what brought you both to science in the first place?
And what do you say to those claiming
you're stomping all over Mother Nature, playing God in the lab?
Uh...
[chuckles]
Well, that's a pretty reductionist way of thinking about things.
But I got into biology because I wanted to understand the laws of nature, not...
Uh, you know, we don't have too many kissing bugs
because there's a fault with those natural laws.
We have too many kissing bugs
because we have made such an horrendous mess of things, OK.
So, far from... from...
I don't know, trying to dominate Mother Nature,
I am in Mother Nature's service.
-[Shay mumbles] That's cute.
-And you, Mr. Levine?
I am just in it for the money.
[laughter]
I might let Shay finish this off.
He's got more than enough to say for both of us.
Uh... Herm...
why don't you...
Yeah.
Thank you, everyone, for coming.
It's been a great day for NIS.
And I'd just like to say we're extremely proud of our...
Would it actually kill you to admit that what we did was a big deal?
It actually means something.
I'm happy to. But I'm not gonna do it like some performing seal.
We don't owe those people anything.
Let alone a peek into our souls,
that they're gonna turn into some cheap bullshit sound bite
for morons to chew up and spit out three minutes later.
You're gonna... You're gonna have to help me out a bit here.
Things aren't great on the home front. It's just this...
It's just this whole baby thing, you know.
We have to stay connected to this monitoring app for the next month
and every day it's just like...
It's like watching her getting stabbed in the face.
"You are not pregnant. You are not pregnant. You're not..."
Like she could forget.
And you know what the worst thing is...
it's like, for two years, I have had my hand in the fire
and now I'm finally able to take it out.
And I just want to punch myself in the face,
'cause all I feel is just relief that this horror show is over.
But every day since we've given up...
she gets further away from me.
It's like when she sees me, she looks at me, she sees her pain.
[scoffs]
Thank you.
For what?
[scoffs] For not...
you know, for not saying anything.
Thanks.
Anytime.
[clattering]
-[woman] I need to get out of here!
-[Eadie] Hey, hey, hey.
She's got no ID. She won't even tell me her name.
- Won't or can't? - [woman whimpers]
I know I don't always want to do what I'm told, but...
Hey. My name's Eadie.
Can you tell me your name?
No? OK.
Do you know it?
No.
[Eadie] OK. That's OK.
It's so hot in here.
Do you want to, um, come and get some fresh air
and we can make a bit of a plan?
Yeah? Just go for a little walk.
So, if we work backwards,
you remember getting off the bus here, yeah?
Yeah?
How about getting on the bus?
This last one came from the Central West,
so you would have got on at, um...
Dubbo?
Millthorpe?
Oberon?
Um...
Yeah?
Yeah. So maybe... Maybe you live in Oberon?
Maybe you were caught up in the storm there last night?
Do you know what day it is?
Tuesday?
You're doing good.
Can you tell me something that's happening in the news?
Something current?
Weather's turned to shit.
- Nausea? - Mm.
Headache?
OK.
Can you hold your hands up?
Grab my hands.
Make fists, really tight.
Great.
Don't let me pull your arms down, OK.
Good.
Well, I think it's safe to say you don't work in a nail salon.
Honest hands. That's what my um...
My...
Are you married?
Maybe.
So, there's no external injuries,
then the first thing we consider is a traumatic brain injury.
A knock to the head and things haven't resettled properly.
-[Abel] Has rice arrived yet?
Oh, as I speak. You're too good, people.
To be sure, she needs an MEG scan
and without any ID credentials, that's gonna be a hard one to pull off.
We're a little low on brain tech.
And unless it's an emergency,
you won't be able to get her into your hospital, correct?
Any ideas?
I'll bring it back. I promise.
I heard you were never here.
Maybe that's why you're not answering my calls.
You've disappeared off the face of the earth.
Sorry.
Have you been doing the injections yourself?
No, I uh...
You tell me you've gotten a new support person, I'm gonna feel very cheated.
You're off the hook.
I'm so sorry, babe.
When?
A couple of days ago.
You didn't call me.
No, I just um...
I just needed to do this one on my own.
Of course. Sorry. That was so needy of me.
I'm sorry. Look, I'm... around if you need me.
And I'm not around if you don't.
[helicopter whirring]
Where's that going? Um...
Hey, boss, can I just get your signature real quick?
- OK. - Thank you.
Well, it's not his decision if he goes to school or not, Chesca. It's ours.
Yeah, and every time you let him get away with it... No, I'm just saying...
I'm just saying that if there's a real problem
and we need to get away in a hurry,
it doesn't matter if he likes the way it feels or not.
[door shuts]
Yeah, I know.
I'm sorry.
OK.
I'll see if I can swing by this afternoon.
Bye.
-Cosmo?
Yeah, I'm running drills with them at the moment.
Unless he gets 24 hours notice and some sheepskin earmuffs, he can't cope.
So, give them to him?
You know when the shit hits the fan,
you're just gonna pick him up and get the hell outta there.
So why put all of you through it?
At the end of the day, remind me to fire you.
I'm taking the kids away for the weekend. You can get the early train.
Denillo's have booked a pick-up.
Quick taxi run to the airport.
Better fire up the limo.
[pilot] What, are you coming?
Yeah, they've just upgraded to premium customers,
so Harlow wants to make sure they get looked after by a partner.
- [Eadie] So let me talk you through what I'm seeing.
I'm seeing swelling here,
which is one of the markers we'd expect from a traumatic brain injury.
What I'm also seeing are
some pretty significant changes to your dopamine receptors.
What does that mean?
It means you've been cooking yourself a pretty intense pharmaceutical habit
for the last couple of years.
Probably one of the peptide-based analgesics like Oliceridine or Fentanyl.
Here and here, that's structural change to the neural pathways.
And all of this red activity here, that's acute opioid withdrawal.
That's the good news.
Because it accounts for part of why you feel so bad.
You're up to your eyeballs in cold turkey.
In time that will subside.
Is that why I can't remember anything?
I just fried my brain?
I don't think so.
But it's so noisy in there right now,
it's like trying to hear a pin drop in the middle of the freeway.
We just need to ride out the withdrawal
until we can get a better picture of what's actually happening.
A junkie, eh?
What a first thing to know.
[Abel] Our support team will take it from here.
If she was getting her fix over the counter, we'll be able to track a file.
It's a Schedule 8 drug and you can't get it without a thumb print anymore.
I think we'll keep you after all.
Well, don't put yourself out.
[helicopter whirrs]
[pilot] Wondered how you'd feel about me taking Mo out
for a flight next weekend?
It's his birthday.
Wow, he's gonna love that.
You'll be dad of the year.
Let's get these guys out and take an early mark.
[helicopter powering down]
Lou, how are you?
Good. Good to see you. We're not quite ready, though.
Miles isn't feeling so good.
-[woman] Nice and slow.
That's it. Just nice and slow.
Hey, guys. It's Miles, right?
Hi, Miles.
- Can I, um...? - Yeah.
Hi there.
I'm Dom.
I need you to squeeze both my hands, OK.
That feeling of not being able to breathe is the worst, right?
Excellent.
Hearing you loud and clear.
Now, the key is I need to find out whether
this feeling's coming from the outside in or the inside out.
So I need a really big two-handed squeeze
if you're feeling wired and nothing if you're feeling tired.
OK. This is more like a panic attack.
- So what we need is... Have you got a bag? - [Miles] Yep.
Hey... [whispers] I have these too. You'll be fine.
[Miles] Here you go, Dom.
I want you to breathe into this very high-tech paper bag
and that'll bring your carbon dioxide levels down
and the world will start looking like a much happier place.
There you go.
He'll be fine.
[woman] That's it, darling.
A serotonin reuptake inhibitor would make the flight a whole lot easier,
stop him having another attack in the air.
[woman] Good boy.
- [Lou] If we hang around for another two hours waiting for a prescription,
we're gonna miss our flight.
We've got a list of tame pharmacists on the books.
We can email through a script request.
And picking up?
Tully will be more than happy to drive into town and get it for you.
Absolutely. Happy as Larry.
- Thank you. That's brilliant. - It's all part of the service.
You haven't got a tame plumber on the books as well,
because I've got a shitfight in the bathroom I don't know what to do about.
[gurgling]
[sigh]
Leave you to it while I pop down the shops, boss.
Unless you want to swap jobs.
What's going on?
- Tried to call you. - What?
I ran some more numbers. I wanted to double check.
- We double checked. - Triple check.
The CCR5 fertility deletions came out with a different set of coordinates.
The DNA changes hitched a ride on the transposons.
I tested it on other insects.
Crosses the species barrier, so...
whatever eats our bug gets its fertility bombed too.
We're a long way from ready.
We have to push the pause button.
-[Eadie] Hey, it's me again.
Been watching you break the internet.
I'm so proud of you.
Wish I'd been there.
The centre is...
It's tougher going than I thought it would be.
Anyway, just call me when you get sick of all the glory.
I love you.
[sombre music]
-[Eadie] Rachel Elleanor Mawson,
born 28th of July 1998.
You had your tonsils out when you were six.
And you broke your arm playing netball when you were 13.
Then a back injury two years ago,
after a tractor accident on your farm.
You had surgery to remove part of a herniated disc.
That's where the Fentanyl came in.
I could find prescriptions for six months.
After that, you must have been getting them in other ways.
You married Gianni Reece seven years ago.
He's quite handsome, right?
This is your family home.
It belonged to your mum and dad.
And her mum before that.
Are they alive, um, my parents?
They both passed.
The year after, you gave birth to Louisa Mae.
She's seven.
What hap...
Do you know where they are?
I put a call in to the Emergency Services at Ashton.
There was a lot of damage to your house.
So there's a good chance that they're in one of the evacuation shelters.
I got some things from the hospital
to help take the edge off some of your withdrawal symptoms.
Start off with a patch.
OK.
Once the withdrawal starts to subside, my memory's gonna start to come back, right?
[phone rings] Seriously? Now?
Answer call.
-[Tully] Uh, Dom.
Stopped off for a coffee, have we?
- Yeah, I've stumbled into a situation here at the pharmacy.
[shouting in background]
Bit of a hold-up actually. It's alright. Woah, woah!
- Tully? - [Tully] It's alright.
- [Tully] We can work this out. - Tully, what's going on?
- [man] Work out?! - [Tully] Listen! [gun shot]
[tense atmospheric music]
[no audible dialogue]
-[Abel] Welcome, sisters.
Welcome, brothers.
As we come together to give thanks for what we have,
even in the face of what we have lost.
[solemn music]
[no audible dialogue]
-[Abel] Some of us have lost homes.
Homes we built or grew up in.
Some have lost possessions, special things,
sacred things, handed down over generations.
Some have lost loved ones.
In that loss, that stripping down,
when we lose the things that say who we are,
who we think we are.
When we don't have the car that says how much we earn,
or which team we barrack for,
which party we vote for,
what school our kids got into,
what brands we let do our talking for us.
All those things, those attachments,
those aversions,
those stories...
And what's left, it's not what makes us different.
It's what makes us the same.
And without all that crap...
Sorry, kids.
We've got a chance of seeing that.
Seeing that we all want the same thing.
We want to be loved.
We want to feel safe.
And it would be easy to despair and to think where is the sanity in all this,
where is the sense.
And if God floats your boat, maybe you're asking, "Where is God in all this?"
Maybe in the dark hours of the night, you're thinking that God is punishing us.
[baby cries]
Or Mother Nature is trying to rid herself of some overgrown parasitic infection.
[baby cries]
But this, frightening and destructive as it is...
-[Rachel] It's OK, baby.
Is God lamenting with us.
[baby cries] - [Rachel] I've got you.
- [Abel] It is the mourning and weeping of Mother Nature. It's not a punishment.
- [girl] Mumma! Mumma! It's a message about what we've done
and what we need to do differently.
I've got you. I've got you.
Mummy needs to go for help, OK?
[Abel] Before it goes cold.
I need you to stay here and look after Daddy.
You sit tight and just stay in the car, alright?
And before you know it, we'll be home.
We'll have a hot chocolate and a bath.
And your job...
Your job is to think about how many chapters we read before sleep.
OK?
-[Abel] To give thanks for this day,
to honour those lost,
to appreciate this excellent dinner.
Two, four, six, eight,
bog in, don't wait. [laughs]
[Rachel whimpers, sobs]
[sombre music]
Rachel?
We ran off the road. I think I walked for help.
I left them there.
OK. Let me put a call in...
Eadie. The hospital's on the phone. I think it's urgent.
Thanks. Um, just give me one minute, OK.
[solemn music]
Oh, Bear.
I called his wife on the way here.
I told her he was gonna be OK.
I lied.
The world's gone mad.
[tense music]