1 00:00:03,525 --> 00:00:04,787 [WATER RUNNING] 2 00:00:10,184 --> 00:00:11,228 [SHOWER DOOR OPENS] 3 00:00:11,402 --> 00:00:12,012 Oh![GIGGLES] 4 00:00:18,279 --> 00:00:21,847 We can't both shower at the same time, Lea. 5 00:00:22,022 --> 00:00:24,372 One of us would block the steam of water for the other. 6 00:00:24,546 --> 00:00:26,635 Oh, Shaun, this is not for the purpose of cleanliness. 7 00:00:26,809 --> 00:00:29,116 This is for the purpose of having sex with you. 8 00:00:30,813 --> 00:00:32,510 Oh. 9 00:00:32,684 --> 00:00:34,643 N... No. No. 10 00:00:34,817 --> 00:00:36,862 It would be inconvenient, possibly dangerous. 11 00:00:37,037 --> 00:00:39,169 Soap might get into difficult places. 12 00:00:39,343 --> 00:00:40,736 If we leaned against the shower handle, 13 00:00:40,910 --> 00:00:41,824 we could scald ourselves. 14 00:00:41,998 --> 00:00:44,522 Bottles could be disarranged. 15 00:00:44,696 --> 00:00:46,133 It was just a thought. 16 00:00:46,307 --> 00:00:48,265 It was a bad thought. 17 00:00:48,439 --> 00:00:49,440 I'm surprised. 18 00:00:49,614 --> 00:00:50,615 You're such an intelligent person. 19 00:00:52,574 --> 00:00:54,880 I'll... Reset your alarm. 20 00:00:59,363 --> 00:01:01,583 DR LIM: It's a three-day weekend and a full moon. 21 00:01:01,757 --> 00:01:03,411 People are gonna do stupid things. 22 00:01:03,585 --> 00:01:06,022 I'm asking everyone to take an extra trauma call in the ER. 23 00:01:06,196 --> 00:01:07,980 Make yourselves available if you're needed. 24 00:01:08,155 --> 00:01:09,982 Questions? 25 00:01:10,157 --> 00:01:12,202 How'd you get the bruise? 26 00:01:12,376 --> 00:01:13,464 First casualty of the full moon. 27 00:01:13,638 --> 00:01:14,900 I smacked my head on a cupboard door 28 00:01:15,075 --> 00:01:15,988 when I was reaching for my coffee mug. 29 00:01:16,163 --> 00:01:17,642 Any other questions? 30 00:01:17,816 --> 00:01:20,297 Why is there a Subaru in your parking space? 31 00:01:20,471 --> 00:01:21,907 Because it's my car. 32 00:01:22,082 --> 00:01:23,909 You have a car? 33 00:01:24,084 --> 00:01:25,085 You're gonna be seeing a lot of it. I sold the Ducati. 34 00:01:25,259 --> 00:01:26,173 What? No. 35 00:01:26,347 --> 00:01:27,565 It just wasn't practical. 36 00:01:27,739 --> 00:01:28,653 Is it already gone? Because... 37 00:01:28,827 --> 00:01:31,221 A guy from Craigslist snatched it up. 38 00:01:31,395 --> 00:01:33,658 Any other questions... Not dealing with the bike? 39 00:01:36,139 --> 00:01:37,662 It wasn't that much of a bruise. 40 00:01:37,836 --> 00:01:39,229 [CELLPHONE CHIMES] 41 00:01:39,403 --> 00:01:41,405 But the doctor at the ski resort told us 42 00:01:41,579 --> 00:01:43,407 I might develop a hematoma? 43 00:01:43,581 --> 00:01:46,236 It's not unusual, but it'll need to be drained. 44 00:01:46,410 --> 00:01:49,196 I see you were treated for melanoma six years ago, 45 00:01:49,370 --> 00:01:51,023 and, more recently, breast cancer. 46 00:01:51,198 --> 00:01:52,373 Hence the ski trip. 47 00:01:52,547 --> 00:01:55,115 A celebration. 48 00:01:55,289 --> 00:01:56,899 One year cancer-free. Also five years cancer-free. 49 00:01:57,073 --> 00:01:59,771 [CELLPHONE CHIMES] 50 00:01:59,945 --> 00:02:03,993 I don't suppose a long needle will be involved in this? 51 00:02:04,167 --> 00:02:05,951 Your hematoma extends pretty deep, 52 00:02:06,126 --> 00:02:07,605 so the needle will have to be long. 53 00:02:07,779 --> 00:02:09,520 But it's over quickly. 54 00:02:09,694 --> 00:02:11,218 Sorry, I have to intervene before this deal goes south. 55 00:02:11,392 --> 00:02:14,873 You don't mind if I step out? 56 00:02:15,047 --> 00:02:17,354 Would you like us to wait for your husband to come back? 57 00:02:17,528 --> 00:02:19,356 No. 58 00:02:19,530 --> 00:02:20,183 Let's go ahead. 59 00:02:24,622 --> 00:02:26,146 DR REZNICK: How do you get frostbite in San Jose? 60 00:02:26,320 --> 00:02:27,625 Cryotherapy accident. 61 00:02:27,799 --> 00:02:29,714 I stayed in the booth a little too long. 62 00:02:29,888 --> 00:02:31,629 I was going to stand outside for the full three minutes, 63 00:02:31,803 --> 00:02:33,283 but he said...I said, "No need." 64 00:02:33,457 --> 00:02:35,329 I'd set the stopwatch on my phone, 65 00:02:35,503 --> 00:02:37,722 after which, my thoughts immediately drifted, and... 66 00:02:37,896 --> 00:02:39,376 I came back to find him frozen in carbonite. 67 00:02:39,550 --> 00:02:40,899 [CHUCKLES] 68 00:02:41,073 --> 00:02:43,337 You know, I'm more worried about the fever. 69 00:02:43,511 --> 00:02:44,599 Was the cryotherapy meant to treat something? 70 00:02:44,773 --> 00:02:46,557 No. Routine self-care. 71 00:02:46,731 --> 00:02:48,385 We've made life extension part of our health regime... 72 00:02:48,559 --> 00:02:51,519 Supplements, meditation, exercise. 73 00:02:51,693 --> 00:02:53,347 Three of my gaming apps have gone viral. 74 00:02:53,521 --> 00:02:55,740 I'm lucky enough to afford basically whatever I want, 75 00:02:55,914 --> 00:02:58,352 so I spend it on my health. 76 00:02:58,526 --> 00:03:01,790 No, I figure fever, must be an infection. 77 00:03:01,964 --> 00:03:04,880 Well, I know that frostbite can make you vulnerable. 78 00:03:05,054 --> 00:03:09,667 It just... It didn't seem severe enough to... 79 00:03:09,841 --> 00:03:12,017 Oh, sorry. I feel a little queasy. 80 00:03:12,192 --> 00:03:13,236 Aah! 81 00:03:13,410 --> 00:03:14,063 Wyatt. 82 00:03:14,237 --> 00:03:15,238 Ow! 83 00:03:21,897 --> 00:03:23,725 [BEEPING] 84 00:03:23,899 --> 00:03:25,596 I need a medical transport team, stat. 85 00:03:25,770 --> 00:03:27,685 Perforated bowel. He needs immediate surgery. 86 00:03:27,859 --> 00:03:30,340 [THEME MUSIC PLAYING] 87 00:03:37,869 --> 00:03:40,045 No. No. Why do people hate wind farms? 88 00:03:40,220 --> 00:03:42,091 Everyone thinks they're noisy. 89 00:03:42,265 --> 00:03:43,745 This could make a turbine sound as quiet 90 00:03:43,919 --> 00:03:45,050 as a page turning in a library. 91 00:03:45,225 --> 00:03:46,704 That's not worth our investing in? 92 00:03:46,878 --> 00:03:48,097 Did you even look... Hold on. 93 00:03:48,271 --> 00:03:49,838 Anything I need to know? 94 00:03:50,012 --> 00:03:51,187 Hematoma's drained. 95 00:03:51,361 --> 00:03:52,971 We're sending a sample to Pathology... Routine. 96 00:03:53,145 --> 00:03:54,451 Should have it back sometime tomorrow. 97 00:03:54,625 --> 00:03:56,801 Thank you. Mm-hmm. 98 00:03:56,975 --> 00:03:59,369 I couldn't help overhearing a little. 99 00:03:59,543 --> 00:04:02,285 Are you a venture capitalist? 100 00:04:02,459 --> 00:04:04,766 The only people who ask me if I'm a VC 101 00:04:04,940 --> 00:04:06,811 are people who want a VC to invest in their project. 102 00:04:09,161 --> 00:04:12,687 Maybe, after we get your wife healthy again, we could talk? 103 00:04:12,861 --> 00:04:13,775 Call whenever you're ready. 104 00:04:13,949 --> 00:04:15,864 My life is listening to ideas. 105 00:04:16,038 --> 00:04:17,039 If it's good, I'll run it by my two partners. 106 00:04:17,213 --> 00:04:18,954 If it's really good, 107 00:04:19,128 --> 00:04:20,347 we'll take a 30% equity position in your company. 108 00:04:22,697 --> 00:04:24,829 Yeah. 109 00:04:25,003 --> 00:04:26,440 Yeah, you're the one who wanted us to get into clean technology. 110 00:04:28,746 --> 00:04:30,357 I think I've been asked out on a date. 111 00:04:32,315 --> 00:04:33,577 Nice. 112 00:04:33,751 --> 00:04:35,187 No, I work with him. 113 00:04:35,362 --> 00:04:36,754 Hasn't stopped you before.I supervise him. 114 00:04:36,928 --> 00:04:37,886 Schedules can be changed. 115 00:04:38,060 --> 00:04:39,801 He's polyamorous. 116 00:04:39,975 --> 00:04:42,847 Unless he also texted you a ring, it's just a date. 117 00:04:43,021 --> 00:04:44,109 And you need to get out more. 118 00:04:45,763 --> 00:04:46,634 So do I. 119 00:04:49,463 --> 00:04:50,115 [GLOVES SNAP] 120 00:04:53,075 --> 00:04:55,860 DR ANDREWS: You want to take down the splenocolic ligament. 121 00:04:56,034 --> 00:04:58,863 Just don't nick the inferior mesenteric artery. 122 00:04:59,037 --> 00:05:02,650 ASHER: I feel the I.M.A. under my finger. 123 00:05:02,824 --> 00:05:04,826 Placing the stapler. 124 00:05:05,000 --> 00:05:06,958 And cutting. 125 00:05:07,132 --> 00:05:08,525 I voted "approve." 126 00:05:11,920 --> 00:05:13,400 Disapprove. 127 00:05:13,574 --> 00:05:14,966 No opinion. 128 00:05:15,140 --> 00:05:16,098 There's a poll? 129 00:05:16,272 --> 00:05:18,840 Yes... About shower sex. 130 00:05:19,014 --> 00:05:21,364 I know it's wrong to discuss shower sex at work, 131 00:05:21,538 --> 00:05:23,061 so I did a poll instead. 132 00:05:23,235 --> 00:05:24,933 Much better. 133 00:05:25,107 --> 00:05:26,761 Dr. Murphy, do you really want people knowing the details 134 00:05:26,935 --> 00:05:28,458 of your personal life? 135 00:05:28,632 --> 00:05:32,157 You don't think they took it as an abstract question? 136 00:05:32,332 --> 00:05:34,595 No. We all take it as something that happened between you and Lea. 137 00:05:34,769 --> 00:05:35,987 And that there was a fight. 138 00:05:36,161 --> 00:05:37,728 DR PARK: Sometime before 8:00 a.m. today, 139 00:05:37,902 --> 00:05:39,513 which was when the poll was sent out. 140 00:05:41,253 --> 00:05:43,168 You are very astute. 141 00:05:43,343 --> 00:05:46,041 I'm seeing diffuse dilation of the large bowel here. 142 00:05:46,215 --> 00:05:48,435 Is that normal? 143 00:05:48,609 --> 00:05:51,568 Some calcified lesions. 144 00:05:51,742 --> 00:05:53,265 Wall's thin, too. 145 00:05:53,440 --> 00:05:54,919 Hirschsprung's. 146 00:05:55,093 --> 00:05:56,443 I thought Hirschsprung's was a disease only babies 147 00:05:56,617 --> 00:05:57,357 and young children got. 148 00:05:57,531 --> 00:05:59,576 It is. 149 00:05:59,750 --> 00:06:00,403 But he has it. 150 00:06:09,281 --> 00:06:11,196 We treated the Hirschsprung's 151 00:06:11,371 --> 00:06:12,459 by removing the dilated part of your colon. 152 00:06:12,633 --> 00:06:14,765 It won't impact your life, 153 00:06:14,939 --> 00:06:16,114 but we would like an explanation. 154 00:06:16,288 --> 00:06:17,594 DR PARK: Dr. Murphy doesn't mean 155 00:06:17,768 --> 00:06:18,813 we expect you to be a diagnostician. 156 00:06:18,987 --> 00:06:20,423 It's just... 157 00:06:20,597 --> 00:06:22,251 This was kind of singular. 158 00:06:22,425 --> 00:06:24,993 So, if you have any thoughts... 159 00:06:25,167 --> 00:06:27,604 Did anyone in your family suddenly develop these symptoms? 160 00:06:31,956 --> 00:06:35,438 I did something singular to myself about six months ago. 161 00:06:35,612 --> 00:06:38,267 I modified my genetic code. 162 00:06:38,441 --> 00:06:40,748 I did a CRISPR procedure under the guidance of some researchers 163 00:06:40,922 --> 00:06:42,271 I know in China through my work. 164 00:06:42,445 --> 00:06:44,142 They put together a series of cocktails. 165 00:06:44,316 --> 00:06:48,320 They FedExed them to be, and Sophie helped me inject them 166 00:06:48,495 --> 00:06:49,626 into my bone marrow. 167 00:06:49,800 --> 00:06:51,280 Why? 168 00:06:51,454 --> 00:06:52,803 If you know anything about CRISPR, 169 00:06:52,977 --> 00:06:54,979 you know how risky it is to tinker with your genome. 170 00:06:55,153 --> 00:06:57,634 You have no idea what problems you might let loose. 171 00:06:57,808 --> 00:06:59,984 I needed to optimize my telomerase activity. 172 00:07:00,158 --> 00:07:01,682 It's the enzyme responsible for correcting 173 00:07:01,856 --> 00:07:02,900 cell replication errors, 174 00:07:03,074 --> 00:07:03,988 essentially, the cause of aging. 175 00:07:04,162 --> 00:07:05,337 SHAWN: You can't stop aging 176 00:07:05,512 --> 00:07:07,557 through changing your telomerase activity. 177 00:07:07,731 --> 00:07:10,908 You might extend your life a little, but exercise... 178 00:07:11,082 --> 00:07:13,520 It does the same thing. Much less risky. 179 00:07:13,694 --> 00:07:15,391 Your decision makes no sense. 180 00:07:15,565 --> 00:07:18,699 Extending my life by a few years is only my short-term goal. 181 00:07:18,873 --> 00:07:20,831 Look, you know how fast medicine is moving. 182 00:07:21,005 --> 00:07:22,964 The day isn't that far away when cloning 183 00:07:23,138 --> 00:07:25,706 will make transplants as easy as switching out a light socket. 184 00:07:25,880 --> 00:07:27,577 AI will start to make breakthroughs 185 00:07:27,751 --> 00:07:29,274 that we can't predict or understand. 186 00:07:29,449 --> 00:07:32,582 Medical knowledge will rise exponentially. 187 00:07:32,756 --> 00:07:34,758 There are babies born now who could live to see it, 188 00:07:34,932 --> 00:07:36,847 could live to be 1,000 years old. 189 00:07:37,021 --> 00:07:38,501 Maybe more. Maybe forever. 190 00:07:38,675 --> 00:07:41,373 Or at least, as long as they want to. 191 00:07:41,548 --> 00:07:43,680 So, our plan is to give my CRISPR a year 192 00:07:43,854 --> 00:07:45,769 to make sure the telomerase change works, 193 00:07:45,943 --> 00:07:47,597 and then we'll do her. 194 00:07:50,165 --> 00:07:52,297 We'll aspirate a sample of your bone marrow. 195 00:07:52,472 --> 00:07:53,690 See if we can figure out what the hell you did. 196 00:07:55,953 --> 00:07:57,041 [ELEVATOR BELL DINGS] 197 00:08:01,655 --> 00:08:02,873 Hey. 198 00:08:03,047 --> 00:08:07,051 Um... I don't think coffee's a good idea. 199 00:08:07,225 --> 00:08:09,053 Entire civilizations rely on it. 200 00:08:09,227 --> 00:08:10,968 But I don't think you're referring to the beverage itself. 201 00:08:11,142 --> 00:08:13,014 I don't think it's a good idea for first-years 202 00:08:13,188 --> 00:08:14,450 and fourth-years to go out. 203 00:08:14,624 --> 00:08:17,235 I am bound to supervise you at some point in the future, 204 00:08:17,409 --> 00:08:20,325 and it'd get complicated trying to change dates out, 205 00:08:20,500 --> 00:08:23,503 and the fact is... 206 00:08:23,677 --> 00:08:26,418 Seeing somebody you work with rarely ends happily. 207 00:08:26,593 --> 00:08:28,246 So, I appreciate you thinking of me, but I... 208 00:08:28,420 --> 00:08:31,728 Oh, you thought it was a date. 209 00:08:31,902 --> 00:08:33,600 I'm still new here, and I thought it was 210 00:08:33,774 --> 00:08:36,864 a good opportunity to get to know each other. 211 00:08:37,038 --> 00:08:38,996 Coffee's perfect because you're asking 212 00:08:39,170 --> 00:08:41,521 the least amount of commitment from another human being. 213 00:08:41,695 --> 00:08:43,914 It's not even lunch. 214 00:08:44,088 --> 00:08:46,047 If it's still a "no," it's still a "no," 215 00:08:46,221 --> 00:08:47,875 but I'll let you re-think your answer. 216 00:09:01,932 --> 00:09:04,500 He only claimed it wasn't a date to save face. 217 00:09:04,674 --> 00:09:06,807 Or maybe I just assumed. 218 00:09:06,981 --> 00:09:08,417 But why did I assume? 219 00:09:08,591 --> 00:09:10,462 I don't think I'm some kind of narcissist 220 00:09:10,637 --> 00:09:13,944 who thinks every man wants to get close to me. 221 00:09:14,118 --> 00:09:17,034 Or we both assumed it's a date because it's a date. 222 00:09:17,208 --> 00:09:19,080 This is fun. I like being your bestie. 223 00:09:19,254 --> 00:09:20,168 Slumber party? 224 00:09:23,737 --> 00:09:26,870 [DOOR OPENS] 225 00:09:27,044 --> 00:09:29,220 I made a poll to test the popularity of shower sex. 226 00:09:29,394 --> 00:09:30,874 I heard. 227 00:09:31,048 --> 00:09:33,094 I fielded some questions about that. 228 00:09:33,268 --> 00:09:37,054 "Approve" has won, but don't get too excited, Lea. 229 00:09:37,228 --> 00:09:39,927 It's only 58-38, 230 00:09:40,101 --> 00:09:42,407 with several complicated noncommittals, 231 00:09:42,582 --> 00:09:44,540 so clearly my attitude is reasonable. 232 00:09:44,714 --> 00:09:47,064 We don't have room for a... 233 00:09:47,238 --> 00:09:49,240 Skier exercise thing. 234 00:09:49,414 --> 00:09:51,765 I'm only putting it together so I can take a picture 235 00:09:51,939 --> 00:09:53,723 and sell it online. 236 00:09:53,897 --> 00:09:55,464 Why do you have it if you don't want it? 237 00:10:01,513 --> 00:10:05,169 My ex sent it. 238 00:10:05,343 --> 00:10:06,823 "Ex"? 239 00:10:06,997 --> 00:10:09,957 Husband. 240 00:10:10,131 --> 00:10:12,133 I left this thing in the attic 241 00:10:12,307 --> 00:10:14,265 until I got settled somewhere with enough space. 242 00:10:14,439 --> 00:10:15,876 And okay, that was 10 years ago, 243 00:10:16,050 --> 00:10:17,268 but it's not like it was in his way. 244 00:10:21,882 --> 00:10:25,668 We got married, not for long, right out of high school. 245 00:10:25,842 --> 00:10:27,365 Literally the boy next door. 246 00:10:27,539 --> 00:10:29,585 We grew up together. People expected it. 247 00:10:29,759 --> 00:10:33,023 It... Was a big mistake. 248 00:10:33,197 --> 00:10:34,546 We both realized it pretty quickly. 249 00:10:40,161 --> 00:10:41,945 ENRIQUE: Why would you even want to live forever? 250 00:10:42,119 --> 00:10:42,642 You'd be bored out of your mind. 251 00:10:42,816 --> 00:10:43,860 [CHUCKLES] 252 00:10:44,034 --> 00:10:45,601 The person I am now 253 00:10:45,775 --> 00:10:50,388 is miles away from the person I was at 14. 254 00:10:50,562 --> 00:10:53,609 I only get more distant every year. 255 00:10:53,783 --> 00:10:58,179 You learn to understand, 256 00:10:58,353 --> 00:11:01,704 love books that you once hated, 257 00:11:01,878 --> 00:11:04,881 sometimes people you once hated. 258 00:11:05,055 --> 00:11:09,407 Music that you didn't get the point of becomes magical. 259 00:11:09,581 --> 00:11:11,540 And a thousand new doors will open. 260 00:11:11,714 --> 00:11:14,021 I look forward to the adventure. 261 00:11:14,195 --> 00:11:15,544 [NEEDLE SQUELCHES]Ow. 262 00:11:15,718 --> 00:11:17,764 Sorry. Adventure's not always gonna be fun. 263 00:11:19,679 --> 00:11:22,943 I figure it takes 40 or 50 years 264 00:11:23,117 --> 00:11:25,728 just to get over the things your parents did. 265 00:11:25,902 --> 00:11:27,512 If only we lived long enough, 266 00:11:27,687 --> 00:11:30,864 the human race might finally have a chance to grow up. 267 00:11:38,001 --> 00:11:39,960 What size shoes do you wear? 268 00:11:40,134 --> 00:11:43,093 Seven and a half. 269 00:11:43,267 --> 00:11:45,356 "Dr. Allen's Walking On Clouds Inserts." 270 00:11:45,530 --> 00:11:47,576 Putting "doctor" in the name is always good marketing strategy. 271 00:11:47,750 --> 00:11:50,231 They're designed to reduce inflammation 272 00:11:50,405 --> 00:11:52,059 that could lead to plantar fasciitis, 273 00:11:52,233 --> 00:11:55,192 calluses, arthritis, and they feel damn good. 274 00:11:55,366 --> 00:11:56,933 Does this have anything to do with our patient's 275 00:11:57,107 --> 00:11:58,021 venture capitalist husband? 276 00:11:58,195 --> 00:11:59,719 I need testimonials. 277 00:11:59,893 --> 00:12:00,763 Labs and Path for Hannah Palmer. 278 00:12:04,985 --> 00:12:07,639 Aren't we all busy enough learning how to be surgeons? 279 00:12:07,814 --> 00:12:09,729 Do you really want to divide your focus onto something trivial? 280 00:12:15,560 --> 00:12:17,954 Because wanting to make money taints the purity of medicine? 281 00:12:20,130 --> 00:12:21,871 I have five brothers. 282 00:12:22,045 --> 00:12:24,308 I've been taking care of people my whole life. 283 00:12:24,482 --> 00:12:27,790 Someone got hurt, they came to me to patch them up. 284 00:12:27,964 --> 00:12:31,359 I became a doctor so I could get paid for it, 285 00:12:31,533 --> 00:12:34,362 but also because I'm good at taking care of people. 286 00:12:34,536 --> 00:12:36,146 It's possible to do something for more than one reason. 287 00:12:48,071 --> 00:12:49,203 The news is bad. 288 00:12:58,821 --> 00:13:02,042 There's an abnormally healthy population 289 00:13:02,216 --> 00:13:05,306 of hematopoietic progenitor stem cells. 290 00:13:05,480 --> 00:13:07,656 He did it?It's significant. 291 00:13:07,830 --> 00:13:10,659 He's succeeded in optimizing enough telomerase activity 292 00:13:10,833 --> 00:13:13,357 to potentially add 10 years to his natural life. 293 00:13:13,531 --> 00:13:15,664 DR ANDREWS: Well, assuming it doesn't subtract about 50. 294 00:13:15,838 --> 00:13:17,274 There's already an autoimmune reaction 295 00:13:17,448 --> 00:13:18,362 that mimics Hirschsprung's. 296 00:13:18,536 --> 00:13:20,321 Who knows what else he did? 297 00:13:20,495 --> 00:13:22,497 What if this is the opposite of an auto-immune condition? 298 00:13:22,671 --> 00:13:23,933 What if he's done something 299 00:13:24,107 --> 00:13:25,326 that lowers his resistance to infection? 300 00:13:25,500 --> 00:13:27,763 Then we'd be seeing more opportunistic infections 301 00:13:27,937 --> 00:13:29,112 of the lungs and skin. 302 00:13:29,286 --> 00:13:31,332 If you lived another 1,000 years, 303 00:13:31,506 --> 00:13:33,073 would you be with the same person at the end 304 00:13:33,247 --> 00:13:34,552 as at the beginning? 305 00:13:34,726 --> 00:13:35,466 No.No. 306 00:13:37,077 --> 00:13:38,687 No, if you assume monogamy. 307 00:13:38,861 --> 00:13:40,689 I mean, that puts too much strain on a relationship. 308 00:13:40,863 --> 00:13:42,517 Is one person supposed to be everything to another, 309 00:13:42,691 --> 00:13:44,475 all the time, for 1,000 years? 310 00:13:44,649 --> 00:13:48,479 Apparently Jesus agrees. On monogamy. 311 00:13:48,653 --> 00:13:50,742 He said that, in Heaven, there'll be no more marriages. 312 00:13:50,917 --> 00:13:54,050 I guess humans can't sustain a relationship that long. 313 00:13:54,224 --> 00:13:55,443 You read the New Testament, too? 314 00:13:55,617 --> 00:13:58,185 And the Qur'an. And other things. 315 00:13:58,359 --> 00:13:59,490 It's like you're a stalker. 316 00:13:59,664 --> 00:14:01,971 It's like you and God had an acrimonious divorce. 317 00:14:02,145 --> 00:14:05,757 What if he caused neurofibromatosis? 318 00:14:05,932 --> 00:14:07,934 Microscopic tumors forming on the nerve sheath? 319 00:14:08,108 --> 00:14:09,326 Mm. Possible, but there'd have been 320 00:14:09,500 --> 00:14:10,414 some evidence of Schwann cell growth 321 00:14:10,588 --> 00:14:12,199 around his colon. 322 00:14:12,373 --> 00:14:14,418 Would you still love your wife in 1,000 years? 323 00:14:16,899 --> 00:14:18,945 You have three answers. That should be enough. 324 00:14:19,119 --> 00:14:20,947 Park's marriage failed in far less time, 325 00:14:21,121 --> 00:14:22,426 and Enrique doesn't even try. 326 00:14:22,600 --> 00:14:24,080 Asher is an... 327 00:14:24,254 --> 00:14:25,690 Unknown quantity. 328 00:14:25,865 --> 00:14:27,170 You're committed. 329 00:14:27,344 --> 00:14:28,432 You've made promises. 330 00:14:31,305 --> 00:14:33,263 I've made promises based on 331 00:14:33,437 --> 00:14:37,093 an understood human life-span, Murphy. 332 00:14:37,267 --> 00:14:40,270 Most likely diagnosis is autoimmune polyneuropathy. 333 00:14:40,444 --> 00:14:41,706 It damaged the enteral ganglion nerve 334 00:14:41,881 --> 00:14:43,491 and led to the perforations. 335 00:14:43,665 --> 00:14:45,797 Start him on steroids and immunosuppressants. 336 00:14:45,972 --> 00:14:47,190 Dr. Andrews. 337 00:14:47,364 --> 00:14:49,410 So, you wouldn't have gotten married 338 00:14:49,584 --> 00:14:51,281 if you thought it would be forever. 339 00:14:51,455 --> 00:14:53,849 You expect all relationships to fail over time. 340 00:14:54,023 --> 00:14:55,198 It's just a question of how long? 341 00:14:57,287 --> 00:14:59,811 I love her now. 342 00:14:59,986 --> 00:15:04,207 I intend to love her as long as I live. 343 00:15:04,381 --> 00:15:08,472 But, eventually, everything breaks. 344 00:15:17,742 --> 00:15:18,961 I always go back to comfort reading 345 00:15:19,135 --> 00:15:20,484 when I'm in the hospital. 346 00:15:20,658 --> 00:15:22,269 Cozy mysteries in little English villages, 347 00:15:22,443 --> 00:15:24,010 where nothing bad happens to anyone we like. 348 00:15:26,490 --> 00:15:28,188 We've gotten your results back. 349 00:15:28,362 --> 00:15:28,971 When will your husband be... 350 00:15:29,145 --> 00:15:30,146 Is it cancer? 351 00:15:32,801 --> 00:15:33,758 Yes. 352 00:15:36,413 --> 00:15:38,938 Thyroid carcinoma. 353 00:15:39,112 --> 00:15:40,722 We're gonna do a complete imaging series 354 00:15:40,896 --> 00:15:41,505 to pinpoint just how advanced... 355 00:15:41,679 --> 00:15:44,247 Treatment? 356 00:15:44,421 --> 00:15:47,250 Surgery to remove some or all of your thyroid 357 00:15:47,424 --> 00:15:49,687 is usually the first line of defense. 358 00:15:49,861 --> 00:15:52,560 Sometimes, we can wait, but given the hematoma 359 00:15:52,734 --> 00:15:56,520 was probably caused by the tumor invading nearby vasculatures, 360 00:15:56,694 --> 00:15:59,088 we should probably do it in the next few days.[WHEEZES] 361 00:15:59,262 --> 00:16:02,004 Later, there'll be radioactive iodine treatment... 362 00:16:02,178 --> 00:16:03,440 [WHEEZES] 363 00:16:03,614 --> 00:16:04,920 Panic attack? 364 00:16:05,094 --> 00:16:07,923 [WHEEZING] 365 00:16:11,231 --> 00:16:12,449 Her trachea's deviated to the right. 366 00:16:12,623 --> 00:16:14,582 The tumor's compressing it. We're doing surgery now. 367 00:16:14,756 --> 00:16:16,540 [GROANING] 368 00:16:20,805 --> 00:16:23,547 [MONITOR BEEPING] 369 00:16:27,464 --> 00:16:28,857 What happened? The nurse just said "surgery." 370 00:16:29,031 --> 00:16:31,294 Was it the hematoma? 371 00:16:31,468 --> 00:16:32,556 It's more serious. 372 00:16:34,602 --> 00:16:36,778 I... It's not cancer... 373 00:16:36,952 --> 00:16:38,823 Again. 374 00:16:38,998 --> 00:16:41,739 Thyroid carcinoma. 375 00:16:41,913 --> 00:16:44,655 We've removed her thyroid. She's doing well. 376 00:16:44,829 --> 00:16:46,266 We're looking into potential causes... 377 00:16:46,440 --> 00:16:48,572 Genetic, environmental. 378 00:16:48,746 --> 00:16:51,662 There may be a deeper issue that we can find and address. 379 00:17:02,456 --> 00:17:06,068 I can't do this. 380 00:17:06,242 --> 00:17:08,984 You've done it before. 381 00:17:09,158 --> 00:17:11,117 You'll do it this time. 382 00:17:16,557 --> 00:17:19,386 Do you know what it's like... 383 00:17:19,560 --> 00:17:20,648 To wake up every morning and know your wife 384 00:17:20,822 --> 00:17:21,823 might not be here next year? 385 00:17:24,217 --> 00:17:27,655 All those treatments... 386 00:17:27,829 --> 00:17:31,006 They all... They all have this little tag attached to them 387 00:17:31,180 --> 00:17:34,140 that says, "Because she might die." 388 00:17:34,314 --> 00:17:38,013 And you see them put those gloves on 389 00:17:38,187 --> 00:17:39,145 before they hook up the chemo. 390 00:17:39,319 --> 00:17:42,278 You know why they do that. 391 00:17:42,452 --> 00:17:43,627 It's because it's poison. 392 00:17:46,021 --> 00:17:49,503 And you sit there... 393 00:17:49,677 --> 00:17:52,593 And you watch them shove poison into the person you love. 394 00:17:52,767 --> 00:17:55,900 And why? 395 00:17:56,075 --> 00:17:57,859 Because she might die. 396 00:18:00,557 --> 00:18:02,951 We're killing her because she might die. 397 00:18:07,999 --> 00:18:09,044 Go for a run. 398 00:18:09,218 --> 00:18:12,178 Go punch a wall. 399 00:18:12,352 --> 00:18:13,788 You need to release some endorphins. 400 00:18:13,962 --> 00:18:15,398 My release is my job. 401 00:18:15,572 --> 00:18:17,183 That's why I love it. 402 00:18:17,357 --> 00:18:20,229 My work requires total focus. 403 00:18:20,403 --> 00:18:21,578 And every minute I'm working 404 00:18:21,752 --> 00:18:24,320 is a minute I'm not thinking about... 405 00:18:24,494 --> 00:18:25,321 Losing her. 406 00:18:31,284 --> 00:18:32,241 I have to go. 407 00:18:38,639 --> 00:18:41,642 Your pain and weakness are consistent with polyneuropathy, 408 00:18:41,816 --> 00:18:44,471 treatable with steroids and immunosuppressants. 409 00:18:44,645 --> 00:18:46,995 If you live 1,000 years, will you still love Sophie? 410 00:18:49,867 --> 00:18:51,042 Yes. 411 00:18:51,217 --> 00:18:53,001 How can you be sure? 412 00:18:53,175 --> 00:18:55,656 People change. You expect to change. 413 00:18:55,830 --> 00:18:59,007 Sophie and I will change together. 414 00:18:59,181 --> 00:19:00,139 We'll go through the same adventures 415 00:19:00,313 --> 00:19:01,357 and learn the same lessons. 416 00:19:01,531 --> 00:19:04,099 What if you go through the same adventures 417 00:19:04,273 --> 00:19:05,448 and learn different lessons? 418 00:19:05,622 --> 00:19:08,625 Even if we did, whoever, whatever we become, 419 00:19:08,799 --> 00:19:10,627 Sophie will always be beautiful. 420 00:19:10,801 --> 00:19:13,500 I mean, she could turn into a machine or a set of pixels 421 00:19:13,674 --> 00:19:16,329 or a giant purple flower, and she'll still be beautiful, 422 00:19:16,503 --> 00:19:18,722 because it's part of her essential nature. 423 00:19:22,639 --> 00:19:24,641 But if you don't know how you'll change, 424 00:19:24,815 --> 00:19:26,252 you don't know how you'll change. 425 00:19:26,426 --> 00:19:29,037 Shaun. 426 00:19:29,211 --> 00:19:30,473 We'll let you get some rest. 427 00:19:30,647 --> 00:19:32,388 The steroids should make you feel a lot better. 428 00:19:38,916 --> 00:19:44,008 Why didn't you ever mention you had an ex-husband? 429 00:19:44,183 --> 00:19:48,056 Shaun, I've barely thought about him in years. 430 00:19:48,230 --> 00:19:51,712 I didn't mention him because he's not important. 431 00:19:51,886 --> 00:19:55,063 I know. That's the problem. 432 00:19:55,237 --> 00:19:58,240 At one time, you felt he was important enough to your life 433 00:19:58,414 --> 00:20:01,591 to marry him, and now you barely think of him. 434 00:20:01,765 --> 00:20:05,204 You make long-term plans, you have expectations, 435 00:20:05,378 --> 00:20:07,075 and then something happens to you, 436 00:20:07,249 --> 00:20:11,514 and suddenly you're a different person. 437 00:20:11,688 --> 00:20:16,737 I know you don't like change, but it's not all bad. 438 00:20:16,911 --> 00:20:21,220 After all, you are working to change yourself all the time. 439 00:20:21,394 --> 00:20:27,182 I'm working to be a better surgeon, a better boyfriend, 440 00:20:27,356 --> 00:20:29,228 better at the things I've chosen, 441 00:20:29,402 --> 00:20:31,360 but this... 442 00:20:31,534 --> 00:20:32,492 Other change... It's unpredictable. 443 00:20:32,666 --> 00:20:33,667 You don't choose it. 444 00:20:33,841 --> 00:20:36,104 It just comes at you. 445 00:20:36,278 --> 00:20:38,889 Oh, it's like hurricanes before 1873, 446 00:20:39,063 --> 00:20:41,065 when the Army Signal Corps first put up flags 447 00:20:41,240 --> 00:20:42,545 to warn people storms were coming. 448 00:20:42,719 --> 00:20:45,592 Before that, houses were flattened, lives destroyed, 449 00:20:45,766 --> 00:20:47,202 and there was no way to see it was heading for you. 450 00:20:47,376 --> 00:20:50,031 Shaun. 451 00:20:50,205 --> 00:20:53,252 Our relationship will not end in natural disaster. 452 00:20:53,426 --> 00:20:54,818 It did begin in one. 453 00:20:57,517 --> 00:21:00,302 I'm going to look in on my patient. 454 00:21:00,476 --> 00:21:02,043 Okay. 455 00:21:09,746 --> 00:21:13,010 Blood and saliva will tell us if there's a genetic cause, 456 00:21:13,184 --> 00:21:14,969 and the samples we take from your house 457 00:21:15,143 --> 00:21:16,449 will tell us if there's something environmental. 458 00:21:18,712 --> 00:21:22,281 I know it's s... Stupid. 459 00:21:22,455 --> 00:21:25,109 I've almost felt guilty for my cancer, 460 00:21:25,284 --> 00:21:28,852 like I arbitrarily decided to be sick and burdensome. 461 00:21:31,725 --> 00:21:33,248 Do the people you're close to 462 00:21:33,422 --> 00:21:35,859 ever act like you're a burden to them? 463 00:21:36,033 --> 00:21:36,860 You mean Alan. 464 00:21:39,298 --> 00:21:41,648 He's scared. 465 00:21:41,822 --> 00:21:45,695 He takes the exit he's got and he turns to his work. 466 00:21:45,869 --> 00:21:47,088 You're okay with that? 467 00:21:55,183 --> 00:21:57,141 I accept this compromise. 468 00:21:57,316 --> 00:21:58,317 That's not the hard part. 469 00:21:58,491 --> 00:22:00,536 The hard part is... 470 00:22:00,710 --> 00:22:03,974 Not knowing. 471 00:22:04,148 --> 00:22:08,327 Each new thing that happens, I worry, "Is this it? 472 00:22:08,501 --> 00:22:11,808 "Is this where I lose him? 473 00:22:11,982 --> 00:22:13,244 "Is this where he breaks?" 474 00:22:20,904 --> 00:22:23,211 CLAIRE: So, this is boiled coffee. 475 00:22:23,385 --> 00:22:25,082 Some people call it "Turkish coffee," 476 00:22:25,256 --> 00:22:28,129 or "Greek coffee," or "Egyptian coffee"... 477 00:22:28,303 --> 00:22:29,435 Because we need to take ownership 478 00:22:29,609 --> 00:22:30,610 and put things in categories. 479 00:22:30,784 --> 00:22:32,394 Yeah. 480 00:22:32,568 --> 00:22:34,222 You actually live in this thing, 481 00:22:34,396 --> 00:22:36,311 in the hospital parking garage? 482 00:22:36,485 --> 00:22:37,399 Why not? 483 00:22:37,573 --> 00:22:38,922 Convenient for work. 484 00:22:39,096 --> 00:22:41,577 When I want to spend a few days off the beaten track, 485 00:22:41,751 --> 00:22:43,666 it's convenient for that, too. 486 00:22:43,840 --> 00:22:46,626 Ooh. I'm gonna get three sips in this. 487 00:22:46,800 --> 00:22:48,018 But three really great sips. 488 00:22:50,456 --> 00:22:52,240 That's how I try to live my life... 489 00:22:52,414 --> 00:22:55,939 Try to appreciate, savor, not pass by. 490 00:22:59,682 --> 00:23:02,859 Is that what the polyamory is about? 491 00:23:03,033 --> 00:23:05,427 Does it really work, or is it one of those theories about life 492 00:23:05,601 --> 00:23:07,124 that people regret later? 493 00:23:07,298 --> 00:23:08,517 No regrets so far. 494 00:23:08,691 --> 00:23:10,301 Mm-hmm. No, I guess not. 495 00:23:10,476 --> 00:23:13,392 Not while you're young and having fun. 496 00:23:13,566 --> 00:23:14,654 It is fun, 497 00:23:14,828 --> 00:23:16,220 but not for the reasons that you're thinking. 498 00:23:16,395 --> 00:23:18,788 It isn't about sex. 499 00:23:18,962 --> 00:23:21,661 It's about commitment, emotional connection. 500 00:23:21,835 --> 00:23:23,924 The joy I'm sure you get out of a relationship, 501 00:23:24,098 --> 00:23:25,099 I get a little more. 502 00:23:25,273 --> 00:23:27,362 Also, I have to give a little more. 503 00:23:27,536 --> 00:23:29,625 But that's meaningful, too. 504 00:23:29,799 --> 00:23:32,498 Hmm. 505 00:23:32,672 --> 00:23:34,282 Do you mind if I ask you something, 506 00:23:34,456 --> 00:23:35,544 since we're getting personal? 507 00:23:39,635 --> 00:23:41,507 Sure. 508 00:23:41,681 --> 00:23:43,465 What's your favorite misheard song lyric? 509 00:23:45,641 --> 00:23:47,991 [LAUGHS] 510 00:23:52,256 --> 00:23:53,301 This is nice. 511 00:23:55,695 --> 00:23:58,088 I'm glad it's not a date. 512 00:23:58,262 --> 00:23:59,742 Me, too. 513 00:23:59,916 --> 00:24:01,048 I don't believe in those categories. 514 00:24:06,662 --> 00:24:08,447 [MACHINE BEEPING]He reported widespread bilateral pain, 515 00:24:08,621 --> 00:24:09,535 then he keeled over. 516 00:24:09,709 --> 00:24:10,971 B.P. dropped to 80 over palp. 517 00:24:11,145 --> 00:24:12,233 I'll order a vasopressor. 518 00:24:12,407 --> 00:24:14,061 Already did.Good. 519 00:24:14,235 --> 00:24:17,891 We need an EKG, CBC, and chest images, and a new diagnosis. 520 00:24:18,065 --> 00:24:20,589 Whatever he caused with CRISPR, it's not just neuropathy. 521 00:24:20,763 --> 00:24:22,025 Something else is killing him. 522 00:24:30,556 --> 00:24:32,253 What if he's caused something that mimics 523 00:24:32,427 --> 00:24:33,559 carcinomatous autonomic neuropathy? 524 00:24:33,733 --> 00:24:35,996 It explains the B.P. and bowel issue. 525 00:24:36,170 --> 00:24:38,346 That doesn't explain the sensory issue that led to the frostbite. 526 00:24:42,045 --> 00:24:43,830 A connective tissue disorder? 527 00:24:44,004 --> 00:24:44,961 That would have shown up on the scans. 528 00:24:45,135 --> 00:24:45,614 His chest looks normal. 529 00:24:51,925 --> 00:24:52,708 Maybe we can't think of the answer 530 00:24:52,882 --> 00:24:54,318 because there is no answer. 531 00:24:54,493 --> 00:24:56,190 We keep trying to jam it into these categories we know, 532 00:24:56,364 --> 00:24:57,452 the diseases that we know. 533 00:24:57,626 --> 00:25:00,237 But this never existed before. 534 00:25:00,411 --> 00:25:02,152 He created a new combination of genetic code. 535 00:25:02,326 --> 00:25:04,328 That means a new combination of symptoms. 536 00:25:04,503 --> 00:25:06,548 DR ANDREWS: So, we shouldn't be looking at what fits the picture, 537 00:25:06,722 --> 00:25:07,897 but at what's closest to the picture, 538 00:25:08,071 --> 00:25:09,899 so we can at least figure out a treatment. 539 00:25:10,073 --> 00:25:13,773 And what it's closest to is amyloidosis. 540 00:25:13,947 --> 00:25:16,515 This isn't an autoimmune neuropathy, 541 00:25:16,689 --> 00:25:19,039 so the nerves must be under attack by something else. 542 00:25:19,213 --> 00:25:21,171 Something like amyloid disease could leave deposits 543 00:25:21,345 --> 00:25:23,652 along the nerves, causing the symptoms we've seen. 544 00:25:23,826 --> 00:25:25,262 Where do we look for those deposits? 545 00:25:25,436 --> 00:25:27,090 The spleen. 546 00:25:33,967 --> 00:25:35,229 Drink all 8 ounces. 547 00:25:35,403 --> 00:25:38,362 We talked. We had a few laughs. 548 00:25:38,537 --> 00:25:40,016 Well, sounds date-y to me. 549 00:25:40,190 --> 00:25:41,452 [GROANS] 550 00:25:41,627 --> 00:25:43,019 I don't think Enrique's a player. 551 00:25:43,193 --> 00:25:44,804 No, he's kind of the opposite of a player. 552 00:25:44,978 --> 00:25:47,067 With him, emotional connection is the point. 553 00:25:47,241 --> 00:25:49,417 He's trying to live some idealistic fantasy 554 00:25:49,591 --> 00:25:51,027 where everyone is nice and no one is jealous. 555 00:25:51,201 --> 00:25:52,855 I am so staying away. 556 00:25:53,029 --> 00:25:54,291 Well, of course. 557 00:25:54,465 --> 00:25:55,075 Once I heard "emotional connection," 558 00:25:55,249 --> 00:25:56,859 I knew the game was over. 559 00:25:57,033 --> 00:25:58,252 What does that mean? 560 00:25:58,426 --> 00:26:00,341 I'm against emotion? 561 00:26:00,515 --> 00:26:02,038 [CHUCKLES] I'm not the one with "cold-hearted bitch" 562 00:26:02,212 --> 00:26:04,127 as my social media hashtag. 563 00:26:04,301 --> 00:26:05,302 She's an excellent doctor. 564 00:26:05,476 --> 00:26:06,913 Every time you've loved somebody, 565 00:26:07,087 --> 00:26:08,567 it's ended in disappointment or death... 566 00:26:08,741 --> 00:26:09,785 Sometimes both. 567 00:26:09,959 --> 00:26:11,308 It's like a reflex now. 568 00:26:11,482 --> 00:26:14,224 You just expect that everything ends badly, so why start? 569 00:26:14,398 --> 00:26:17,793 So, despite the many practical reasons not to go out 570 00:26:17,967 --> 00:26:19,490 with a first-year, this is all about me? 571 00:26:19,665 --> 00:26:23,059 Is that a diamond ring? 572 00:26:23,233 --> 00:26:24,452 I mean, it's pretty. 573 00:26:24,626 --> 00:26:26,062 Our patient caught her fiance cheating. 574 00:26:26,236 --> 00:26:27,890 Big fight. He demanded the ring back. 575 00:26:28,064 --> 00:26:29,413 She swallowed it. 576 00:26:29,588 --> 00:26:31,154 I did. 577 00:26:31,328 --> 00:26:31,938 You don't even know if this is "going out," 578 00:26:32,112 --> 00:26:33,679 and that's the point. 579 00:26:33,853 --> 00:26:35,594 It doesn't matter what Enrique's offering. 580 00:26:35,768 --> 00:26:37,683 Whether it's friendship or romance, you're not investing. 581 00:26:37,857 --> 00:26:39,380 You're risk-averse. 582 00:26:39,554 --> 00:26:42,252 Your portfolio right now is entirely in T-Bills and money market. 583 00:26:42,426 --> 00:26:43,776 I have no idea what that means. 584 00:26:43,950 --> 00:26:45,212 And it's too bad, because a guy that can make you laugh 585 00:26:45,386 --> 00:26:47,127 might be just what you need right now. 586 00:26:47,301 --> 00:26:49,608 It's progressed to your large intestine. 587 00:26:49,782 --> 00:26:52,436 Here's a plastic bag. Put it over the toilet seat. 588 00:26:52,611 --> 00:26:53,612 You'll have every opportunity to recover your property. 589 00:26:58,529 --> 00:27:01,445 Don't run away from a chance at love. 590 00:27:01,620 --> 00:27:04,666 It's a date... 591 00:27:04,840 --> 00:27:05,841 Maybe. 592 00:27:06,015 --> 00:27:06,625 I don't know. 593 00:27:06,799 --> 00:27:07,626 Oh. 594 00:27:09,889 --> 00:27:11,586 OLIVIA: Her house is full of T.C.E., 595 00:27:11,760 --> 00:27:12,718 a side effect from chip-making 596 00:27:12,892 --> 00:27:14,894 back in Silicon Valley's early days. 597 00:27:15,068 --> 00:27:16,765 So, they move away from their toxic home, 598 00:27:16,939 --> 00:27:18,027 and hopefully things get a little better. 599 00:27:18,201 --> 00:27:19,638 Probably not much. 600 00:27:19,812 --> 00:27:21,335 She also has a genetic predisposition. 601 00:27:21,509 --> 00:27:23,293 It's both? 602 00:27:23,467 --> 00:27:24,773 She shouldn't go outside in a rainstorm. 603 00:27:26,862 --> 00:27:28,559 How do you tell a woman that her third cancer 604 00:27:28,734 --> 00:27:29,648 likely won't be close to her last? 605 00:27:33,564 --> 00:27:35,697 Unfortunately, this is a teaching moment. 606 00:27:38,961 --> 00:27:41,311 Dr. Allen, after 12 hours on duty, 607 00:27:41,485 --> 00:27:44,140 I can report that your inserts came through. 608 00:27:44,314 --> 00:27:46,142 Check your e-mail. You'll find my testimonial. 609 00:27:46,316 --> 00:27:47,274 [EXHALES SHARPLY] 610 00:27:47,448 --> 00:27:48,101 Claire. Olivia. 611 00:27:55,064 --> 00:27:56,413 [EXHALES SHARPLY] 612 00:27:56,587 --> 00:27:59,503 And if you're right, what will you do? 613 00:27:59,678 --> 00:28:02,289 We'll treat the symptoms with targeted drug therapies. 614 00:28:02,463 --> 00:28:04,508 There really isn't a disease, as such, that we can address. 615 00:28:04,683 --> 00:28:05,771 Ow. 616 00:28:12,081 --> 00:28:12,995 The pain shifted? 617 00:28:13,169 --> 00:28:15,606 Yeah. Oh. 618 00:28:15,781 --> 00:28:17,652 Never mind about the ultrasound. 619 00:28:17,826 --> 00:28:19,175 It'll be easier to check for deposits after the organ's been removed. 620 00:28:19,349 --> 00:28:20,829 After it's...Yeah. 621 00:28:21,003 --> 00:28:21,961 His spleen's about to rupture. Call a transport team. 622 00:28:24,180 --> 00:28:26,574 [ALARM BEEPING] 623 00:28:26,748 --> 00:28:27,836 [GRUNTS] 624 00:28:35,191 --> 00:28:37,977 It's called Li-Fraumeni Syndrome... LFS. 625 00:28:38,151 --> 00:28:39,805 An inherited predisposition 626 00:28:39,979 --> 00:28:42,895 to developing a wide range of cancers. 627 00:28:43,069 --> 00:28:44,548 Yes, there was a toxin in your environment 628 00:28:44,723 --> 00:28:46,202 that likely played a role in this, 629 00:28:46,376 --> 00:28:48,335 but there will be other triggers in the future. 630 00:28:48,509 --> 00:28:51,077 Your body is super sensitive 631 00:28:51,251 --> 00:28:52,861 and will respond with tumors for the rest of your life. 632 00:29:00,869 --> 00:29:03,480 I know that's a shock, 633 00:29:03,654 --> 00:29:06,309 but here's what you should know... 634 00:29:06,483 --> 00:29:09,312 Most cancers are treatable if found early enough. 635 00:29:13,316 --> 00:29:15,754 We know the most common associated with LFS, 636 00:29:15,928 --> 00:29:18,147 and we can do surveillance, 637 00:29:18,321 --> 00:29:23,413 nip anything in the bud before it becomes a problem. 638 00:29:23,587 --> 00:29:27,287 It may not seem this way now, but this is good. 639 00:29:27,461 --> 00:29:29,332 We know what we're dealing with. 640 00:29:29,506 --> 00:29:31,857 We're warned, and we'll be ready. 641 00:29:40,343 --> 00:29:41,823 He won't be able to handle this. 642 00:29:47,568 --> 00:29:49,788 DR ANDREWS: Liver, pancreas, other organs look normal. 643 00:29:49,962 --> 00:29:51,398 Ah. 644 00:29:51,572 --> 00:29:54,575 But there are calcified lesions along these nerves. 645 00:29:54,749 --> 00:29:56,490 He's gonna be in pain like this for the rest of his life. 646 00:29:56,664 --> 00:29:57,883 SHAUN: No. 647 00:29:58,057 --> 00:29:59,798 There's a reasonable chance it'll get worse 648 00:29:59,972 --> 00:30:01,147 as time goes on. 649 00:30:01,321 --> 00:30:03,627 I need my sharp-blunt curved scissors. 650 00:30:03,802 --> 00:30:05,368 ENRIQUE: What if we used CRISPR to reverse CRISPR? 651 00:30:07,544 --> 00:30:10,156 Researchers have identified a protein in certain bacteria 652 00:30:10,330 --> 00:30:12,419 that inhibits CRISPR. 653 00:30:12,593 --> 00:30:14,551 What if we insert the DNA that makes that protein 654 00:30:14,725 --> 00:30:15,901 into our patient's genome? 655 00:30:16,075 --> 00:30:17,685 That would deactivate the CRISPR gene. 656 00:30:17,859 --> 00:30:19,121 ASHER: So, CRISPR messed him up permanently, 657 00:30:19,295 --> 00:30:20,906 and you think we should do more of it? 658 00:30:21,080 --> 00:30:22,516 I don't know. Our patient is a risk-taker. 659 00:30:22,690 --> 00:30:24,431 We'd need a delivery mechanism. 660 00:30:24,605 --> 00:30:26,737 The code would have to be introduced through a virus... 661 00:30:26,912 --> 00:30:29,262 A virus that specifically targets nerves. 662 00:30:31,481 --> 00:30:33,092 Polio targets nerves. 663 00:30:33,266 --> 00:30:35,050 Because this isn't risky enough. 664 00:30:35,224 --> 00:30:36,791 Polio is such a dangerous virus 665 00:30:36,965 --> 00:30:38,488 because it's so good at penetrating the nervous system. 666 00:30:56,855 --> 00:30:57,725 Dr. Murphy? 667 00:31:02,295 --> 00:31:07,343 She's going to be this way... Forever. 668 00:31:07,517 --> 00:31:10,346 She'll have good periods and bad periods. 669 00:31:10,520 --> 00:31:14,437 But she will always have to be on her guard. 670 00:31:14,611 --> 00:31:18,311 Is she always gonna have to be on guard against you, too? 671 00:31:18,485 --> 00:31:20,052 What does that mean? 672 00:31:20,226 --> 00:31:22,402 Chronic illness puts strain on relationships. 673 00:31:22,576 --> 00:31:25,622 Statistically, it is more often the man who can't handle it. 674 00:31:25,796 --> 00:31:27,929 Our marriage is none of your business. 675 00:31:28,103 --> 00:31:29,844 Her health is my business. 676 00:31:30,018 --> 00:31:31,454 And your behavior adds to her stress. 677 00:31:34,675 --> 00:31:38,113 You look at her, and you imagine she's gone, and that is hard. 678 00:31:38,287 --> 00:31:39,027 I get it. 679 00:31:41,900 --> 00:31:45,425 She thinks the same thing when she looks at you. 680 00:31:45,599 --> 00:31:48,297 I never complain to her. I know it's nobody's fault. 681 00:31:48,471 --> 00:31:50,996 You don't think she knows you have trouble with all this? 682 00:31:51,170 --> 00:31:53,215 Every time something new happens, 683 00:31:53,389 --> 00:31:56,305 she wonders, is this the straw 684 00:31:56,479 --> 00:31:59,787 that is gonna break your marriage? 685 00:31:59,961 --> 00:32:02,572 You've got her living in a constant state of uncertainty. 686 00:32:02,746 --> 00:32:06,228 That is practically the definition of stress. 687 00:32:06,402 --> 00:32:09,971 So, this is the "straighten up and fly right" lecture. 688 00:32:10,145 --> 00:32:11,146 No. 689 00:32:12,974 --> 00:32:16,456 I am... 690 00:32:16,630 --> 00:32:22,853 I'm telling you to consider how best to time your divorce. 691 00:32:23,028 --> 00:32:25,421 There are gonna be a lot of new issues dropping on Hannah, 692 00:32:25,595 --> 00:32:27,206 and if you're gonna end up leaving anyway, 693 00:32:27,380 --> 00:32:28,555 you should start planning now. 694 00:32:28,729 --> 00:32:29,860 I don't want to leave my wife. 695 00:32:30,035 --> 00:32:32,733 My best advice? 696 00:32:32,907 --> 00:32:36,650 Help her through this next round of treatment as best you can, 697 00:32:36,824 --> 00:32:39,870 and then get out. 698 00:32:40,045 --> 00:32:43,526 It's hard living with someone who needs so much. 699 00:32:43,700 --> 00:32:47,226 I know you feel there is a point where you have nothing left, 700 00:32:47,400 --> 00:32:50,185 where you're ready to break. 701 00:32:50,359 --> 00:32:55,016 Just... Don't break when she needs you most. 702 00:32:57,018 --> 00:32:58,541 Get out before that happens. 703 00:33:20,433 --> 00:33:22,783 Reading an article that's five years old? 704 00:33:22,957 --> 00:33:25,481 Dr. Glassman was once involved in an experimental attempt 705 00:33:25,655 --> 00:33:28,049 to treat Parkinson's with CRISPR technology. 706 00:33:28,223 --> 00:33:29,616 It failed. 707 00:33:29,790 --> 00:33:31,618 So, it's both old and it didn't work? 708 00:33:31,792 --> 00:33:33,968 Dr. Glassman likes his failures to be informative. 709 00:33:34,142 --> 00:33:36,014 That's why his articles are longer. 710 00:33:36,188 --> 00:33:37,624 Do you worry about losing the people you love? 711 00:33:44,718 --> 00:33:47,068 Because we can't stop ourselves from changing, 712 00:33:47,242 --> 00:33:49,375 which means we might stop loving someone, 713 00:33:49,549 --> 00:33:50,767 or they might stop loving us. 714 00:33:50,941 --> 00:33:53,074 It is a very bad thing. 715 00:33:53,248 --> 00:33:54,597 It is. 716 00:33:58,166 --> 00:34:02,649 So, no one can ever feel... Safe. 717 00:34:02,823 --> 00:34:06,218 How can you keep going if you never feel safe? 718 00:34:11,049 --> 00:34:13,138 Well, sometimes, not changing is just as dangerous. 719 00:34:16,750 --> 00:34:20,493 So, how do you know when to do what? 720 00:34:20,667 --> 00:34:22,886 [CHUCKLES] 721 00:34:23,061 --> 00:34:24,497 If you find the answer to that, let me know. 722 00:34:31,156 --> 00:34:32,940 I have it.You do? 723 00:34:33,114 --> 00:34:36,161 Dr. Glassman used varicella zoster virus 724 00:34:36,335 --> 00:34:38,902 as the delivery mechanism, which didn't work. 725 00:34:39,077 --> 00:34:40,687 His first choice was herpes simplex, 726 00:34:40,861 --> 00:34:42,732 but the technology was not up 727 00:34:42,906 --> 00:34:44,343 to putting their DNA package into it. 728 00:34:44,517 --> 00:34:46,693 The technology has improved. 729 00:34:46,867 --> 00:34:47,650 It can be done. 730 00:34:52,264 --> 00:34:54,353 [GRUNTS] 731 00:34:54,527 --> 00:34:55,963 Using conventional treatments, 732 00:34:56,137 --> 00:34:58,008 there's nothing more we can do for you. 733 00:34:58,183 --> 00:35:00,228 The pain will be permanent, and it could get worse. 734 00:35:02,274 --> 00:35:07,148 Well, I've not been one to be limited by the conventional. 735 00:35:07,322 --> 00:35:09,498 We think we can reverse the CRISPR. 736 00:35:09,672 --> 00:35:11,805 You want to reverse what I did? My telomerase change? 737 00:35:11,979 --> 00:35:13,328 They want to stop your pain. 738 00:35:13,502 --> 00:35:15,504 Soph, it's temporary. 739 00:35:15,678 --> 00:35:17,289 What is it, 40 years? 740 00:35:17,463 --> 00:35:19,943 That's nothing. Our real lives are ahead of us. 741 00:35:20,118 --> 00:35:22,555 Hey, look, as long as this doesn't kill me, 742 00:35:22,729 --> 00:35:25,166 I've made the right choice, no matter how bad things get. 743 00:35:25,340 --> 00:35:26,341 No. 744 00:35:28,082 --> 00:35:33,000 I was willing to exercise for hours and fast, 745 00:35:33,174 --> 00:35:35,698 to give up all sugar and alcohol 746 00:35:35,872 --> 00:35:38,048 and do all the other things that we needed to do 747 00:35:38,223 --> 00:35:43,271 to get to a future that I knew might never come. 748 00:35:43,445 --> 00:35:47,188 But now, you're asking me to watch you suffer 749 00:35:47,362 --> 00:35:48,711 for the rest of your life. 750 00:35:58,068 --> 00:36:02,377 You're the one who embraces change. 751 00:36:02,551 --> 00:36:07,948 So, change to the person who can be happy with me... 752 00:36:08,122 --> 00:36:09,341 Here and now. 753 00:36:18,872 --> 00:36:20,743 Doctors, would you mind waiting outside? 754 00:36:27,707 --> 00:36:30,927 Why did she want us to leave? 755 00:36:31,101 --> 00:36:32,842 I think she's delivering an ultimatum. 756 00:36:33,016 --> 00:36:34,757 [MATT BERNINGER'S ONE MORE SECONDPLAYS] 757 00:36:43,984 --> 00:36:45,812 ♪♪ The last time... 758 00:36:45,986 --> 00:36:47,727 Are you sure about this? 759 00:36:47,901 --> 00:36:50,164 It seems there's always something else 760 00:36:50,338 --> 00:36:51,557 that I have to give up. 761 00:36:54,429 --> 00:36:57,432 But this isn't like sugar or cigarettes. 762 00:36:57,606 --> 00:36:59,782 You won't get over this in a hurry. 763 00:36:59,956 --> 00:37:01,915 No. 764 00:37:02,089 --> 00:37:03,612 Not in 1,000 years. 765 00:37:06,702 --> 00:37:13,535 ♪♪ And the way we talked Last night 766 00:37:13,709 --> 00:37:15,842 Are you gonna be okay? 767 00:37:16,016 --> 00:37:17,322 I'm fine. 768 00:37:17,496 --> 00:37:20,107 Alan's at work, but there should be a taxi waiting. 769 00:37:20,281 --> 00:37:23,328 I won't say goodbye, Dr. Browne, 770 00:37:23,502 --> 00:37:26,548 'cause I'll probably be seeing you again pretty soon. 771 00:37:26,722 --> 00:37:29,029 ♪♪ Baby, don't lie to me 772 00:37:29,203 --> 00:37:32,032 I sent your cab away. 773 00:37:32,206 --> 00:37:35,035 I'm sorry I wasn't here sooner. 774 00:37:35,209 --> 00:37:38,647 I had to present a proposal to my partners. 775 00:37:38,821 --> 00:37:42,172 ♪♪ Just give me A little more time 776 00:37:42,347 --> 00:37:44,914 ♪♪ Give me a little bit Of warning 777 00:37:45,088 --> 00:37:46,089 ♪♪ Baby, I'm gonna be fine 778 00:37:46,264 --> 00:37:48,004 I'm selling them my share of the business. 779 00:37:48,178 --> 00:37:51,747 ♪♪ When I figure out Where I'm going 780 00:37:51,921 --> 00:37:54,184 Is... Is there something else you want to do? 781 00:37:54,359 --> 00:37:55,795 ♪♪ Why can't You just tell me 782 00:37:55,969 --> 00:37:56,970 Yes. 783 00:37:57,144 --> 00:37:59,364 ♪♪ What you're doing here? 784 00:37:59,538 --> 00:38:00,669 I want to be your husband. 785 00:38:04,107 --> 00:38:08,590 ♪♪ Don't be cruel, If you're leaving me 786 00:38:08,764 --> 00:38:12,594 I realized I was so... 787 00:38:12,768 --> 00:38:17,904 Afraid of losing you in the future... 788 00:38:18,078 --> 00:38:19,035 I was losing you now. 789 00:38:19,209 --> 00:38:21,429 [SNIFFLES] 790 00:38:21,603 --> 00:38:24,606 ♪♪ Give me one more second To dry my eyes 791 00:38:24,780 --> 00:38:27,348 ♪♪ Give me one more day To realize 792 00:38:27,522 --> 00:38:30,656 ♪♪ Smoke's in our eyes Or in the distance 793 00:38:30,830 --> 00:38:33,311 ♪♪ Either way, We're gonna miss it 794 00:38:33,485 --> 00:38:35,878 ♪♪ Give me one more year To get back on track 795 00:38:36,052 --> 00:38:38,925 ♪♪ Give me one more life To win you back 796 00:38:39,099 --> 00:38:42,232 ♪♪ Smoke's in our eyes Or in the distance 797 00:38:42,407 --> 00:38:46,759 ♪♪ Either way, We're gonna miss it 798 00:38:46,933 --> 00:38:49,109 Sorry. 799 00:38:49,283 --> 00:38:50,980 I hear your VC contact decided to quit the business. 800 00:38:54,244 --> 00:38:55,376 He did the right thing. 801 00:38:59,989 --> 00:39:02,470 ♪♪ Baby, don't lie to me 802 00:39:02,644 --> 00:39:05,560 You know... 803 00:39:05,734 --> 00:39:08,433 My feet are killing me. 804 00:39:08,607 --> 00:39:11,871 ♪♪ If it ain't me, come on 805 00:39:12,045 --> 00:39:15,396 ♪♪ Just give me A little more time 806 00:39:15,570 --> 00:39:17,833 ♪♪ Give me a little bit Of warning 807 00:39:18,007 --> 00:39:20,619 ♪♪ Baby, I'm gonna be fine 808 00:39:20,793 --> 00:39:22,272 ♪♪ When I figure out where 809 00:39:22,447 --> 00:39:25,406 ♪♪ Give me one more second To dry my eyes 810 00:39:25,580 --> 00:39:28,017 ♪♪ Give me one more day To realize 811 00:39:28,191 --> 00:39:31,020 ♪♪ Smoke's in our eyes Or in the distance 812 00:39:31,194 --> 00:39:33,675 I'm open. To being friends. 813 00:39:33,849 --> 00:39:35,155 That's great. 814 00:39:35,329 --> 00:39:38,419 I'm open, too, to wherever this goes. 815 00:39:38,593 --> 00:39:41,117 It's going to friendship. 816 00:39:41,291 --> 00:39:42,945 Understood. 817 00:39:43,119 --> 00:39:44,556 But life is about change, 818 00:39:44,730 --> 00:39:46,253 which means, one day, you might change your mind. 819 00:39:46,427 --> 00:39:48,211 And if you did, I'd be open to that, too. 820 00:39:48,386 --> 00:39:49,735 It's not gonna happen. 821 00:39:53,086 --> 00:39:53,826 Okay. 822 00:39:58,308 --> 00:39:59,745 [SIGHS] 823 00:40:15,108 --> 00:40:17,197 First, there should be no soap involved. 824 00:40:17,371 --> 00:40:19,329 Also, we need to stay at one end of the shower, 825 00:40:19,504 --> 00:40:22,028 so we don't accidentally knock into the temperature control. 826 00:40:22,202 --> 00:40:25,248 What changed your mind? 827 00:40:25,423 --> 00:40:28,295 I've been thinking about change over time. 828 00:40:28,469 --> 00:40:30,079 I spoke with people and also graphed 829 00:40:30,253 --> 00:40:31,559 several possibilities for us, 830 00:40:31,733 --> 00:40:33,213 using time as the horizontal axis 831 00:40:33,387 --> 00:40:34,780 and change as the vertical. 832 00:40:34,954 --> 00:40:38,044 I realized that the problem isn't really change. 833 00:40:38,218 --> 00:40:42,091 It's whether two people change in the same direction. 834 00:40:42,265 --> 00:40:43,919 We want to keep our coordinates close to each other 835 00:40:44,093 --> 00:40:47,009 for the rest of our lives. 836 00:40:47,183 --> 00:40:50,099 We certainly do. 837 00:40:50,273 --> 00:40:52,972 But people sometimes do drift apart. 838 00:40:53,146 --> 00:40:54,626 Yes. 839 00:40:54,800 --> 00:40:56,454 You need a warning when you and your partner 840 00:40:56,628 --> 00:40:58,325 might be starting to veer off, 841 00:40:58,499 --> 00:41:00,109 so you can both change course a little. 842 00:41:00,283 --> 00:41:01,937 You don't want a surprise realization when it's too late. 843 00:41:02,111 --> 00:41:03,765 Surprises are awful. 844 00:41:03,939 --> 00:41:06,507 The U.S. Army Signal Corps used flags to warn of hurricanes. 845 00:41:06,681 --> 00:41:08,509 I brought us this. 846 00:41:08,683 --> 00:41:11,599 [CHUCKLES] A cowbell? 847 00:41:11,773 --> 00:41:14,689 If you see us heading in different directions, 848 00:41:14,863 --> 00:41:16,212 you ring it. 849 00:41:16,386 --> 00:41:18,301 Do we really need a bell? Can't I just tell you? 850 00:41:18,476 --> 00:41:19,999 [BELL CLANGS] 851 00:41:20,173 --> 00:41:21,914 Oh! When you ring it, I'll pay attention. 852 00:41:22,088 --> 00:41:23,263 I really hate the sound. 853 00:41:23,437 --> 00:41:27,223 Only in emergencies. 854 00:41:27,397 --> 00:41:31,445 I've already moved the shampoo bottles. 855 00:41:31,619 --> 00:41:33,316 What? 856 00:41:33,491 --> 00:41:34,970 ♪♪ Give me one more second to dry my eyes 857 00:41:35,144 --> 00:41:36,189 Oh. 858 00:41:36,363 --> 00:41:38,365 You mean now? 859 00:41:38,539 --> 00:41:41,847 ♪♪ Smoke's in our eyes Or in the distance 860 00:41:42,021 --> 00:41:43,762 Don't worry about putting the bottles back. 861 00:41:43,936 --> 00:41:44,937 I'll do it later. 862 00:41:45,111 --> 00:41:46,025 [LAUGHS] 863 00:41:46,199 --> 00:41:48,288 I love you. 864 00:41:48,462 --> 00:41:51,117 It's no trouble. I remember where they all go. 865 00:41:51,291 --> 00:41:53,380 ♪♪ Smoke's in our eyes Or in the distance 866 00:41:53,554 --> 00:41:55,817 ♪♪ Either way, We're gonna miss it 867 00:41:58,211 --> 00:41:59,647 [CAR ALARM BEEPS] 868 00:41:59,821 --> 00:42:01,388 ♪♪ Give me one more second To dry my eyes 869 00:42:01,562 --> 00:42:04,391 ♪♪ Give me one more day To realize 870 00:42:04,565 --> 00:42:07,655 ♪♪ Smoke's in our eyes Or in the distance 871 00:42:07,829 --> 00:42:10,528 ♪♪ Either way, We're gonna miss it 872 00:42:10,702 --> 00:42:13,269 ♪♪ Give me one more year To get back on track 873 00:42:13,443 --> 00:42:16,316 ♪♪ Give me one more life To win you back 874 00:42:16,490 --> 00:42:19,537 ♪♪ Smoke's in our eyes Or in the distance 875 00:42:19,711 --> 00:42:21,713 ♪♪ Either way, We're gonna miss it 876 00:42:27,196 --> 00:42:28,371 ♪♪ When it's gone ♪♪