1 00:00:03,442 --> 00:00:05,024 Those are yours. 2 00:00:05,339 --> 00:00:07,664 We bought them together. 3 00:00:07,789 --> 00:00:10,969 Because you "found the pattern soothing." 4 00:00:18,930 --> 00:00:21,429 I'm gonna miss you, Shaun. 5 00:00:21,633 --> 00:00:23,343 I love Carly. 6 00:00:25,150 --> 00:00:26,492 And that's great. 7 00:00:26,580 --> 00:00:28,578 I am so happy for you. 8 00:00:28,666 --> 00:00:32,419 Now you can hang the toilet paper incorrectly 9 00:00:32,507 --> 00:00:33,859 anytime you want. 10 00:00:33,947 --> 00:00:35,335 And Carly and I can go back 11 00:00:35,423 --> 00:00:37,632 to the way things were before our fight. 12 00:00:38,848 --> 00:00:42,203 Well, sometimes couples need a little time to recover. 13 00:00:42,292 --> 00:00:43,388 We won't. 14 00:00:43,476 --> 00:00:46,001 Carly asked for you to move out. 15 00:00:46,088 --> 00:00:48,210 You are moving out. 16 00:00:51,078 --> 00:00:53,656 How many kidneys do I need in my body to attend prom? 17 00:00:53,744 --> 00:00:54,744 Ryan... 18 00:00:54,851 --> 00:00:56,303 Even if the surgery removes my kidney, 19 00:00:56,390 --> 00:00:57,750 it'll be laparoscopic, 20 00:00:57,838 --> 00:01:00,879 so my inpatient time will be seven days, tops. 21 00:01:00,967 --> 00:01:02,882 And then three more days of rest at home. 22 00:01:02,970 --> 00:01:05,143 I can take my girlfriend to prom, right? 23 00:01:06,128 --> 00:01:07,771 That's not a purely medical decision. 24 00:01:07,859 --> 00:01:09,182 I have to draw some blood. 25 00:01:09,303 --> 00:01:11,219 What are the chances Dr. Melendez might be able 26 00:01:11,307 --> 00:01:13,180 to remove the tumor but spare Ryan's kidney? 27 00:01:13,323 --> 00:01:15,113 Well, the MRI will let us know 28 00:01:15,200 --> 00:01:16,840 how much the chemo shrunk the tumor, 29 00:01:16,928 --> 00:01:19,020 but you shouldn't count on it. 30 00:01:19,176 --> 00:01:22,217 One chili burger, extra mustard, extra pickles. 31 00:01:22,460 --> 00:01:24,167 Hi. Morning, Mr. Cooper. 32 00:01:24,255 --> 00:01:25,971 I'm not sure he can have that with his surgery... 33 00:01:26,058 --> 00:01:28,098 Oh, he's fine until about 6:30 tonight. 34 00:01:28,685 --> 00:01:30,017 Claire: I know you. 35 00:01:30,104 --> 00:01:32,644 Angie... Valens. 36 00:01:32,731 --> 00:01:34,271 I helped put in your chemo port. 37 00:01:34,358 --> 00:01:36,773 I owe you a big thank‐you. 38 00:01:36,860 --> 00:01:38,608 We met in chemo. 39 00:01:38,695 --> 00:01:40,736 They should put us in a public service announcement or something. 40 00:01:40,823 --> 00:01:42,863 Yeah... "I lost a tumor and gained a boyfriend. 41 00:01:42,950 --> 00:01:44,031 Thanks, chemo." 42 00:01:48,539 --> 00:01:49,953 James McDougall? 43 00:01:50,040 --> 00:01:51,246 That's who we're here for, too. 44 00:01:51,333 --> 00:01:53,623 All of you can head over to Bay 4. 45 00:01:53,710 --> 00:01:55,876 Guy saw me six months ago for a stress fracture. 46 00:01:55,963 --> 00:01:58,170 He's a lunatic ultra‐marathoner. 47 00:01:58,257 --> 00:01:59,838 I just hope he didn't go too hard too soon 48 00:01:59,925 --> 00:02:01,301 and break it again. 49 00:02:07,349 --> 00:02:09,639 He didn't break it again. 50 00:02:24,137 --> 00:02:26,323 Lim: Your GP was right to start you on ketoprofen for the swelling, 51 00:02:26,410 --> 00:02:28,325 but clearly, it isn't working. 52 00:02:28,412 --> 00:02:29,993 That's why Drs. Murphy and Reznick 53 00:02:30,080 --> 00:02:31,995 are going to block off some of your lymphatic channels. 54 00:02:32,082 --> 00:02:34,039 It should reduce production. 55 00:02:34,126 --> 00:02:36,124 The more pressing concern is why. 56 00:02:36,211 --> 00:02:38,380 Have you ever had surgery on your lymph nodes? 57 00:02:39,590 --> 00:02:42,089 What about cancer or radiation treatment? 58 00:02:42,176 --> 00:02:44,132 No. Physically, I've always been healthy. 59 00:02:44,219 --> 00:02:45,550 Physically? 60 00:02:45,637 --> 00:02:47,650 I was diagnosed with Persistent Depressive Disorder 61 00:02:47,738 --> 00:02:49,429 when I was 16. 62 00:02:49,516 --> 00:02:52,599 That's why you got to get me back out on the road, Doc. 63 00:02:52,686 --> 00:02:54,643 Are antidepressants not effective for you? 64 00:02:54,730 --> 00:02:56,436 I mean, they help. 65 00:02:56,523 --> 00:02:59,106 But running really is key. 66 00:02:59,193 --> 00:03:01,983 Saved my marriage and... and my life. 67 00:03:02,070 --> 00:03:04,528 Lymphedema can be caused by an infection. 68 00:03:04,615 --> 00:03:06,496 He doesn't have a fever. 69 00:03:06,584 --> 00:03:08,281 Ketoprofen can suppress fevers. 70 00:03:08,368 --> 00:03:09,681 Let's get some cultures 71 00:03:09,769 --> 00:03:11,535 and start him on broad‐spec antibiotics. 72 00:03:15,918 --> 00:03:19,459 As requested, your restock on enemas. 73 00:03:19,663 --> 00:03:21,168 Nice cover. 74 00:03:22,216 --> 00:03:23,338 How've you been feeling? 75 00:03:23,425 --> 00:03:25,257 The methotrexate is working great. 76 00:03:25,344 --> 00:03:27,509 No pain, no redness. 77 00:03:27,596 --> 00:03:29,634 Stiffness, flu‐like symptoms? 78 00:03:29,722 --> 00:03:30,853 No. All good. 79 00:03:32,550 --> 00:03:34,057 How long are you planning to hide out 80 00:03:34,159 --> 00:03:37,300 doing RA exams and clipping diabetics' toenails? 81 00:03:38,023 --> 00:03:40,650 Dizziness, headaches, nausea? 82 00:03:40,738 --> 00:03:43,902 I... Sometimes I'm a little queasy after I eat. 83 00:03:44,321 --> 00:03:46,871 You had to love neurosurgery. 84 00:03:47,949 --> 00:03:49,489 How about we try to get you a medication 85 00:03:49,576 --> 00:03:51,199 that doesn't irritate your stomach? 86 00:03:51,286 --> 00:03:54,004 No. My hands feel great. That's all I care about. 87 00:03:54,915 --> 00:03:58,222 You used to open up skulls and poke around people's brains. 88 00:03:58,347 --> 00:04:00,738 There's no way this fulfills you. 89 00:04:00,918 --> 00:04:02,210 I enjoy it. 90 00:04:02,297 --> 00:04:05,172 Or, rather, I usually enjoy it. 91 00:04:07,010 --> 00:04:08,824 I'll let you get back to it. 92 00:04:10,722 --> 00:04:12,910 Maybe someone out there needs an enema. 93 00:04:17,770 --> 00:04:19,268 Got a measurement on the Wilms tumor? 94 00:04:19,356 --> 00:04:21,464 Mm, not quite there yet. 95 00:04:21,692 --> 00:04:24,357 You mentioned 7 centimeters as our limit 96 00:04:24,444 --> 00:04:25,775 to doing this laparoscopically. 97 00:04:25,862 --> 00:04:28,400 What if we pushed it to 7.2? 98 00:04:28,488 --> 00:04:30,285 Would speed up recovery. 99 00:04:30,534 --> 00:04:32,119 By a few days. 100 00:04:33,453 --> 00:04:34,962 Forget I brought it up. 101 00:04:35,050 --> 00:04:37,460 Ryan wanting to take his girlfriend to prom 102 00:04:37,548 --> 00:04:40,733 should not factor into our surgical plan. 103 00:04:40,877 --> 00:04:42,042 Is he nuts about her? 104 00:04:42,129 --> 00:04:45,126 Ohh. Crazy, head over heels in love. 105 00:04:45,214 --> 00:04:46,421 They both are. 106 00:04:46,508 --> 00:04:47,508 Idiots. 107 00:04:49,428 --> 00:04:52,230 I wouldn't mind being an idiot like that again. 108 00:04:53,065 --> 00:04:56,345 Though, I'm not sure I ever felt that way... 109 00:04:56,433 --> 00:04:57,765 totally happy. 110 00:04:57,853 --> 00:04:59,447 So therapy's going well? 111 00:05:00,923 --> 00:05:02,949 No metastasis in the lungs. 112 00:05:04,318 --> 00:05:05,607 Look at that. 113 00:05:11,533 --> 00:05:13,031 Your tumor is gone. 114 00:05:15,291 --> 00:05:16,625 Gone? 115 00:05:17,834 --> 00:05:19,161 How's that possible? 116 00:05:19,249 --> 00:05:21,925 The chemotherapy worked better than we expected. 117 00:05:22,044 --> 00:05:24,605 Wait, like, no tumor? Zero? 118 00:05:24,816 --> 00:05:26,267 No need for surgery whatsoever? 119 00:05:26,355 --> 00:05:27,261 Claire: That is right. 120 00:05:27,349 --> 00:05:29,199 These are discharge forms. 121 00:05:32,332 --> 00:05:34,511 Both of my kidneys are taking you to prom! 122 00:05:34,598 --> 00:05:35,804 Aah! Hell, yeah, we are! 123 00:05:43,355 --> 00:05:44,732 Angie? 124 00:05:46,680 --> 00:05:47,552 Angie! 125 00:05:47,640 --> 00:05:48,774 She's having a seizure! 126 00:05:50,217 --> 00:05:52,549 2 milligrams of lorazepam and portable oxygen, stat. 127 00:05:52,660 --> 00:05:54,418 Let's get that under her head. 128 00:05:57,688 --> 00:05:59,363 His lungs are filled with fluid. 129 00:06:00,746 --> 00:06:03,456 I need a chest X‐ray and a bedside ultrasound. 130 00:06:03,582 --> 00:06:05,597 And page Dr. Reznick. 131 00:06:19,006 --> 00:06:20,339 Imaging has confirmed 132 00:06:20,427 --> 00:06:22,511 a reoccurrence of your brain tumor. 133 00:06:23,563 --> 00:06:25,148 What stage? 134 00:06:25,911 --> 00:06:27,079 3. 135 00:06:28,386 --> 00:06:31,797 The best approach is surgery... a wide resection of the tumor, 136 00:06:31,885 --> 00:06:34,949 followed by radiation and chemo to encourage full remission. 137 00:06:35,909 --> 00:06:38,121 Sounds like a fun couple months. 138 00:06:38,359 --> 00:06:42,488 Full recovery will probably take closer to eight. 139 00:06:47,379 --> 00:06:49,506 We can get through this, baby, just like last time. 140 00:06:51,716 --> 00:06:53,714 W‐When will the surgery be? 141 00:06:54,052 --> 00:06:56,102 We need to do some additional imaging, 142 00:06:56,190 --> 00:06:57,719 and I'd like to consult a colleague 143 00:06:57,807 --> 00:06:59,226 about the best surgical approach. 144 00:06:59,314 --> 00:07:00,534 That'll take a few days. 145 00:07:02,263 --> 00:07:03,612 Take your time. 146 00:07:05,401 --> 00:07:06,569 Prom? 147 00:07:07,607 --> 00:07:08,620 Yeah. 148 00:07:08,708 --> 00:07:10,610 Now that Ryan can go, I have to go. 149 00:07:10,698 --> 00:07:13,667 Honey. This is your health we're talking about. 150 00:07:13,858 --> 00:07:16,316 Mom, please. 151 00:07:16,464 --> 00:07:19,886 I just want to do this one thing like a normal kid. 152 00:07:21,997 --> 00:07:23,957 Can you tell her it's okay? 153 00:07:25,167 --> 00:07:26,245 Park: We can't. 154 00:07:26,333 --> 00:07:28,001 Until we remove your tumor, you're at risk 155 00:07:28,089 --> 00:07:29,994 of potentially fatal seizures. 156 00:07:32,174 --> 00:07:33,546 After you're recovered, 157 00:07:33,633 --> 00:07:35,173 you and Ryan can get all dressed up, 158 00:07:35,260 --> 00:07:36,940 and we'll go have dinner at the Grandview. 159 00:07:37,028 --> 00:07:38,028 Okay? 160 00:07:44,261 --> 00:07:46,017 Prom sucks. 161 00:07:46,206 --> 00:07:47,852 My buddy had a fake ID. 162 00:07:47,939 --> 00:07:49,766 I got so drunk in the limo that I passed out 163 00:07:49,854 --> 00:07:52,107 and never made it into the dance. 164 00:07:52,378 --> 00:07:54,734 Maybe that wasn't everybody's experience. 165 00:07:54,948 --> 00:07:57,128 I was prom king. My date was queen. 166 00:08:01,533 --> 00:08:03,063 I had the dress, I had the date, 167 00:08:03,151 --> 00:08:04,868 I had the mom who got arrested. 168 00:08:04,956 --> 00:08:06,871 Spent the night picking her up from the drunk tank. 169 00:08:06,958 --> 00:08:08,438 Did you see Park while you were there? 170 00:08:09,567 --> 00:08:12,331 Go to scheduling, get Angie's surgery set for Friday... 171 00:08:12,419 --> 00:08:14,254 with the best neurosurgery OR nurses. 172 00:08:16,332 --> 00:08:17,663 Let's go see Glassman. 173 00:08:18,612 --> 00:08:19,964 Andrews: Now I'm identifying 174 00:08:20,052 --> 00:08:21,760 the submillimeter lymphatic vessels. 175 00:08:21,848 --> 00:08:25,464 I need an 11‐0 micro suture and a 70 micron needle. 176 00:08:26,143 --> 00:08:28,518 Instead of harvesting nodes to this area, 177 00:08:28,605 --> 00:08:31,312 could we redirect lymphatics away from his lymph system? 178 00:08:31,399 --> 00:08:32,471 We could. 179 00:08:32,559 --> 00:08:34,753 If you identify an appropriate vessel, 180 00:08:34,861 --> 00:08:36,237 you can make the connection. 181 00:08:36,446 --> 00:08:38,745 Lim: We're clearly not dealing with an infection. 182 00:08:38,907 --> 00:08:41,156 There must be a blockage somewhere in his lymph system. 183 00:08:41,300 --> 00:08:42,949 Most likely cancer. 184 00:08:43,128 --> 00:08:46,456 His CBC didn't show any abnormal cells. 185 00:08:46,544 --> 00:08:48,413 Lymphoma doesn't always show up. 186 00:08:48,500 --> 00:08:51,211 We need to run cytology on his lymphatic fluid. 187 00:08:56,844 --> 00:08:58,995 It's either gonna be nasty or very nasty, 188 00:08:59,083 --> 00:09:02,948 depending upon how it attaches to the thalamus and fornix. 189 00:09:03,171 --> 00:09:07,297 Which no imaging or testing can possibly determine. 190 00:09:07,831 --> 00:09:09,517 So, our options are? 191 00:09:09,604 --> 00:09:12,893 Between an endoscopic approach or an open anterior one. 192 00:09:12,995 --> 00:09:14,442 That is correct. 193 00:09:16,820 --> 00:09:21,290 I'd run a stereotactic MRI with fiducials and DTI 194 00:09:21,378 --> 00:09:24,346 to gauge how close the white matter tracts actually are. 195 00:09:25,453 --> 00:09:26,719 You should scrub in. 196 00:09:28,164 --> 00:09:30,000 Another doctor can cover the clinic. 197 00:09:31,334 --> 00:09:34,375 I haven't been in an OR in over a year, 198 00:09:34,462 --> 00:09:36,294 and then, as a patient. 199 00:09:36,381 --> 00:09:38,338 I'm not asking you to cut. 200 00:09:38,425 --> 00:09:40,673 But it'd be a huge value to have you there. 201 00:09:42,888 --> 00:09:44,385 I appreciate that. 202 00:09:44,823 --> 00:09:46,196 I'll consider it. 203 00:10:00,345 --> 00:10:03,487 Hello. We need to run cytology on this lymphatic fluid. 204 00:10:03,644 --> 00:10:05,354 I would be happy to. 205 00:10:09,239 --> 00:10:11,159 Lea moved out this morning. 206 00:10:13,823 --> 00:10:14,852 Thank you. 207 00:10:14,940 --> 00:10:15,946 You're welcome. 208 00:10:16,034 --> 00:10:17,891 Can you come over tonight? 209 00:10:17,979 --> 00:10:19,504 Uh, that probably won't work... 210 00:10:19,591 --> 00:10:21,448 Or we could go to your apartment? 211 00:10:22,836 --> 00:10:24,129 I can't. 212 00:10:26,190 --> 00:10:28,571 Lea said that it might take time 213 00:10:28,659 --> 00:10:30,565 for us to recover from our fight. 214 00:10:30,653 --> 00:10:32,563 But I told her that we were okay. 215 00:10:32,651 --> 00:10:34,351 We are. 216 00:10:34,573 --> 00:10:36,145 I made plans tonight. 217 00:10:36,323 --> 00:10:39,175 To hang out with a friend who just got fired. 218 00:10:39,861 --> 00:10:42,235 But I would love to come over tomorrow night. 219 00:10:42,948 --> 00:10:44,565 Okay. 220 00:10:44,653 --> 00:10:46,815 I'll put a rush on this test, too. 221 00:10:54,612 --> 00:10:57,266 Your lymphovenous anastomosis technique... 222 00:10:57,354 --> 00:10:58,793 I was impressed. 223 00:10:59,026 --> 00:11:00,735 It's a little early in the morning 224 00:11:00,823 --> 00:11:02,130 to be sucking up, Reznick. 225 00:11:02,217 --> 00:11:04,268 Not for me. I like to get a jump on things. 226 00:11:04,356 --> 00:11:06,594 I'm fascinated by the way you use plastic procedures, 227 00:11:06,682 --> 00:11:09,429 like microsurgery, in other surgical specialties. 228 00:11:09,516 --> 00:11:12,152 I thought it might make an interesting topic for a paper. 229 00:11:12,549 --> 00:11:14,510 Want to write it with me? 230 00:11:15,090 --> 00:11:16,432 Yes. 231 00:11:16,520 --> 00:11:17,646 Let's talk and eat. 232 00:11:20,808 --> 00:11:22,568 That's not breakfast. 233 00:11:23,826 --> 00:11:25,194 I'm buying. 234 00:11:25,435 --> 00:11:27,363 What publications do you want to target? 235 00:11:30,078 --> 00:11:32,327 Last time, Angie had bad post‐op vomiting. 236 00:11:32,414 --> 00:11:34,249 Of course. I'll make note of it... Excuse me. 237 00:11:35,417 --> 00:11:38,240 She's asleep. She needs her rest. 238 00:11:38,420 --> 00:11:40,058 I'll wait out here until she's awake. 239 00:11:40,146 --> 00:11:41,890 Ryan, your immune system is weak. 240 00:11:41,978 --> 00:11:43,713 It would be so easy for you to pick up a bug 241 00:11:43,800 --> 00:11:45,046 and pass it to Angie. 242 00:11:45,134 --> 00:11:47,208 I haven't been around anyone but my dad. I swear. 243 00:11:47,296 --> 00:11:48,805 He could wear a mask. 244 00:11:52,726 --> 00:11:54,057 After Angie's surgery, 245 00:11:54,144 --> 00:11:56,142 we'll see about arranging a visit. 246 00:11:56,229 --> 00:11:57,772 Please tell her Ryan came by. 247 00:12:00,968 --> 00:12:03,399 I'm sorry if I overstepped. 248 00:12:03,843 --> 00:12:05,224 I'd like to change Angie's status 249 00:12:05,335 --> 00:12:06,819 to "No visitors" on her chart. 250 00:12:06,906 --> 00:12:07,987 Yeah. 251 00:12:15,373 --> 00:12:16,929 Please take Mr. McDougall to his room. 252 00:12:17,017 --> 00:12:18,644 I'll be there in a moment. 253 00:12:20,430 --> 00:12:21,897 Is that James McDougall? 254 00:12:22,630 --> 00:12:23,836 And the woman with him? 255 00:12:23,923 --> 00:12:24,963 His wife. 256 00:12:25,050 --> 00:12:26,798 Is it cancer? 257 00:12:27,080 --> 00:12:28,851 No... worse. 258 00:12:29,262 --> 00:12:32,512 His lymphedema is caused by a genetic mutation. 259 00:12:32,788 --> 00:12:35,013 If you don't find a medication he responds to, 260 00:12:35,101 --> 00:12:37,266 he'll drown from the inside. 261 00:12:40,827 --> 00:12:43,796 The mutation is on James' ARAF gene... 262 00:12:43,884 --> 00:12:45,528 it makes an enzyme called kinase, 263 00:12:45,616 --> 00:12:47,777 which can cause cells to overproliferate. 264 00:12:47,972 --> 00:12:49,734 It's a genetic condition. 265 00:12:51,218 --> 00:12:52,532 What set it off now? 266 00:12:52,619 --> 00:12:54,047 Probably the stress fracture. 267 00:12:54,135 --> 00:12:55,660 Sent his immune system into overdrive, 268 00:12:55,747 --> 00:12:57,906 which fired up his lymphatic system. 269 00:12:58,166 --> 00:13:00,123 What treatment protocol targets this mutation? 270 00:13:00,210 --> 00:13:01,874 An MEK inhibitor. 271 00:13:01,961 --> 00:13:03,376 The problem is, which one? 272 00:13:03,463 --> 00:13:07,380 There are 41 possibilities, each with different side effects. 273 00:13:07,860 --> 00:13:09,090 Good luck. 274 00:13:09,575 --> 00:13:11,577 Well, I was hoping you could stay. 275 00:13:15,145 --> 00:13:17,356 Okay. Sure. 276 00:13:19,693 --> 00:13:21,617 We need you to stay completely still. 277 00:13:22,728 --> 00:13:24,164 Not a problem. 278 00:13:25,985 --> 00:13:27,430 You okay? 279 00:13:28,274 --> 00:13:30,069 Ryan totally bailed. 280 00:13:30,156 --> 00:13:31,783 He hasn't come back to see me. 281 00:13:34,672 --> 00:13:36,873 If you tell her that her mom said he couldn't visit, 282 00:13:36,961 --> 00:13:38,326 she'll be pissed at her mom. 283 00:13:38,414 --> 00:13:39,938 How's that gonna help? 284 00:13:42,158 --> 00:13:45,119 He's probably... busy catching up in school. 285 00:13:47,992 --> 00:13:49,589 We had a pact... 286 00:13:49,676 --> 00:13:52,906 as long as we were together, cancer wasn't gonna beat us. 287 00:13:53,883 --> 00:13:55,344 He broke it. 288 00:13:55,719 --> 00:13:57,344 Cancer wins. 289 00:14:02,305 --> 00:14:03,805 Do you mind finishing? 290 00:14:15,688 --> 00:14:16,824 Imaging finished? 291 00:14:16,911 --> 00:14:18,149 Not quite. 292 00:14:18,253 --> 00:14:22,078 Mrs. Valens, Angie would really like to see Ryan. 293 00:14:22,166 --> 00:14:23,748 I know you're concerned about infection, 294 00:14:23,835 --> 00:14:25,249 but there is minimal risk. 295 00:14:25,336 --> 00:14:28,461 Actually... Actually, none, if they do a video chat. 296 00:14:29,351 --> 00:14:30,852 Interesting idea. 297 00:14:31,216 --> 00:14:32,592 I'll think about it. 298 00:14:35,016 --> 00:14:36,511 Angie's depressed. 299 00:14:36,598 --> 00:14:39,096 And studies have shown that that can have a negative impact 300 00:14:39,183 --> 00:14:41,224 on her surgical outcome. 301 00:14:43,929 --> 00:14:47,020 Ryan doesn't always improve Angie's mood. 302 00:14:47,391 --> 00:14:49,795 A couple of weeks ago, they had some silly fight, 303 00:14:49,883 --> 00:14:51,984 and she cried for days. 304 00:14:52,313 --> 00:14:53,694 Thank you for letting me know. 305 00:14:53,906 --> 00:14:55,347 I'm gonna do my best to cheer her up. 306 00:14:55,610 --> 00:14:57,406 She's a 16‐year‐old. 307 00:14:57,493 --> 00:14:59,116 She wants her boyfriend. 308 00:14:59,555 --> 00:15:00,553 Yeah. 309 00:15:00,641 --> 00:15:02,790 And how smart were you when you were 16? 310 00:15:10,131 --> 00:15:12,046 Morgan: Well, what about Selumetinib? 311 00:15:12,133 --> 00:15:14,711 It's shown promising results on related conditions. 312 00:15:14,799 --> 00:15:17,256 And a high occurrence of liver disease. 313 00:15:17,432 --> 00:15:21,414 Binimetinib is similar, but has fewer complications. 314 00:15:22,151 --> 00:15:23,719 Any objections? 315 00:15:26,165 --> 00:15:27,916 Let's start James on that. 316 00:15:35,615 --> 00:15:39,115 This is exciting, working together. 317 00:15:39,202 --> 00:15:40,727 It is. 318 00:15:40,815 --> 00:15:43,776 Although, I'm used to samples and slides 319 00:15:43,864 --> 00:15:45,563 instead of patients. 320 00:15:49,062 --> 00:15:51,811 Patients can be difficult. 321 00:15:51,899 --> 00:15:53,625 But you will be fine. 322 00:16:12,567 --> 00:16:14,102 Do you need something? 323 00:16:15,947 --> 00:16:19,133 I was curious how James was responding to the Binimetinib. 324 00:16:19,360 --> 00:16:20,719 His urine output is up, 325 00:16:20,807 --> 00:16:23,438 which suggests the lymphatic fluid I... 326 00:16:24,313 --> 00:16:25,811 And his potassium is a little low. 327 00:16:25,899 --> 00:16:27,288 Can you... give him this? 328 00:16:27,375 --> 00:16:28,607 I wasn't really... 329 00:16:45,308 --> 00:16:46,458 Hi. 330 00:16:46,546 --> 00:16:48,015 I'm Dr. Lever. 331 00:16:48,139 --> 00:16:50,062 The tumor's abutting and possibly infiltrating 332 00:16:50,150 --> 00:16:51,747 the white matter tracts of her fornix. 333 00:16:51,835 --> 00:16:53,563 We'll likely have to remove a section. 334 00:16:53,651 --> 00:16:55,983 That'll affect her ability to form memories. 335 00:16:56,071 --> 00:16:57,450 With a lot of neuropsych rehab, 336 00:16:57,538 --> 00:16:59,946 she may be able to compensate with other pathways. 337 00:17:00,202 --> 00:17:02,044 Studies have shown that positive attitudes 338 00:17:02,132 --> 00:17:03,523 lead to positive outcomes. 339 00:17:03,611 --> 00:17:04,834 You're worried about her attitude? 340 00:17:04,921 --> 00:17:06,257 She's worried about young love. 341 00:17:06,345 --> 00:17:08,411 I'm worried about what Angie is facing after surgery... 342 00:17:08,498 --> 00:17:10,841 physical therapy, cognitive therapy, 343 00:17:10,929 --> 00:17:12,031 one challenge after another. 344 00:17:12,119 --> 00:17:14,218 And what she wants is so simple. 345 00:17:16,364 --> 00:17:18,156 You want to make a sad kid happy? 346 00:17:19,531 --> 00:17:20,633 I guess I do. 347 00:17:20,720 --> 00:17:22,176 Which isn't my job, and I need to stop 348 00:17:22,263 --> 00:17:23,868 getting sucked into people's personal issues. 349 00:17:23,955 --> 00:17:26,554 Is there a way to do that without antagonizing the mother? 350 00:17:30,313 --> 00:17:31,554 Maybe. 351 00:17:32,874 --> 00:17:34,484 Then make her happy. 352 00:17:51,304 --> 00:17:53,666 We've never gotten this far before. 353 00:17:53,753 --> 00:17:54,968 No. 354 00:17:55,088 --> 00:17:56,419 We haven't. 355 00:17:56,617 --> 00:17:58,398 And you're okay? 356 00:17:59,258 --> 00:18:01,226 I am very okay. 357 00:18:10,603 --> 00:18:11,929 Carly. 358 00:18:12,077 --> 00:18:13,102 Ohh. 359 00:18:26,797 --> 00:18:28,266 Okay. 360 00:18:35,044 --> 00:18:38,711 Did... I do something wrong? 361 00:18:39,264 --> 00:18:41,266 No, I'm sorry. It's me. 362 00:18:42,405 --> 00:18:45,842 You said we were okay. 363 00:18:45,930 --> 00:18:47,404 I thought we were. 364 00:18:47,492 --> 00:18:48,721 I‐I want us to be. 365 00:18:48,808 --> 00:18:50,701 You have no reason to still be mad. 366 00:18:50,789 --> 00:18:51,967 I'm not mad. 367 00:18:52,055 --> 00:18:53,303 I'm... I'm just... 368 00:18:59,672 --> 00:19:00,816 It's Morgan. 369 00:19:00,903 --> 00:19:03,819 The medication caused James an upper GI bleed. 370 00:19:11,664 --> 00:19:13,454 Have you localized the source of the bleeding? 371 00:19:13,541 --> 00:19:14,375 Working on it. 372 00:19:14,463 --> 00:19:16,670 Seems to be coming from the antrum of the stomach. 373 00:19:17,057 --> 00:19:18,471 Morgan: We stopped the Binimetinib. 374 00:19:18,559 --> 00:19:19,508 On top of causing this, 375 00:19:19,596 --> 00:19:21,170 it hadn't done much to curtail the swelling. 376 00:19:21,257 --> 00:19:22,213 Where's Dr. Lever? 377 00:19:22,323 --> 00:19:24,789 There's the ulcerative lesion. Cautery. 378 00:19:27,961 --> 00:19:29,469 Zebrafish. 379 00:19:29,765 --> 00:19:30,846 They're used in medical research 380 00:19:30,933 --> 00:19:32,348 because of their quick maturation, 381 00:19:32,435 --> 00:19:35,076 and 84% of genes associated with human disease 382 00:19:35,164 --> 00:19:36,844 have a zebrafish equivalent. 383 00:19:36,991 --> 00:19:40,466 You think we should do a transgenic expression 384 00:19:40,554 --> 00:19:44,346 of James' ARAF mutation into the zebrafish genome. 385 00:19:44,489 --> 00:19:45,736 Translation for those of us 386 00:19:45,823 --> 00:19:47,446 without a genetics textbook handy? 387 00:19:47,633 --> 00:19:50,092 We make mini‐Jameses, as zebrafish, 388 00:19:50,180 --> 00:19:51,409 all with the same disorder. 389 00:19:51,496 --> 00:19:54,370 Then we test every conceivable drug on those fish. 390 00:19:54,594 --> 00:19:56,247 How long before we can start testing? 391 00:19:56,334 --> 00:19:58,084 If we implant the embryos now, 392 00:19:58,172 --> 00:19:59,667 probably by late afternoon tomorrow. 393 00:19:59,755 --> 00:20:00,875 Get going. 394 00:20:00,963 --> 00:20:03,087 Shaun, go with her. You have Path experience. 395 00:20:24,237 --> 00:20:26,625 I understand no means no. 396 00:20:27,388 --> 00:20:30,516 If you don't want to have sex, 397 00:20:31,485 --> 00:20:33,033 I accept that. 398 00:20:33,313 --> 00:20:35,703 But I am very confused. 399 00:20:36,000 --> 00:20:37,649 So am I. 400 00:20:37,890 --> 00:20:39,930 I thought I was fine u‐until I... 401 00:20:40,017 --> 00:20:43,976 I told Lea to move out, like you wanted. 402 00:20:44,445 --> 00:20:47,341 You said that things were okay. 403 00:20:47,469 --> 00:20:48,606 They aren't. 404 00:20:48,694 --> 00:20:50,383 How do I make them okay? 405 00:20:50,922 --> 00:20:53,555 I can't tell you, because I don't know. 406 00:21:18,164 --> 00:21:19,288 When I was in chemo, 407 00:21:19,375 --> 00:21:21,749 the nurses used to force that stuff down my throat, 408 00:21:21,836 --> 00:21:24,376 so I know you're not drinking it because of the taste. 409 00:21:25,590 --> 00:21:27,219 It's fast, easy nutrition. 410 00:21:27,307 --> 00:21:30,375 That and you don't end up puking your guts out in the bathroom. 411 00:21:31,762 --> 00:21:34,220 I was president of this hospital for over 10 years. 412 00:21:34,307 --> 00:21:37,097 I made a few friends, including Jack the janitor... 413 00:21:37,184 --> 00:21:40,017 talks a lot, A's fan, horrible gossip. 414 00:21:40,297 --> 00:21:42,555 If the methotrexate is making you sick, 415 00:21:42,643 --> 00:21:44,477 we should try another medication. 416 00:21:46,980 --> 00:21:49,732 How can you guarantee that you're not gonna throw up 417 00:21:49,820 --> 00:21:51,883 in the middle of your next surgery? 418 00:21:52,268 --> 00:21:53,728 It won't happen. 419 00:21:54,827 --> 00:21:57,594 Because it only happens if I eat solid food. 420 00:21:57,934 --> 00:21:59,143 And I stopped. 421 00:22:00,425 --> 00:22:02,086 At least at work. 422 00:22:13,408 --> 00:22:15,662 That is a lot of fish tanks. 423 00:22:15,750 --> 00:22:16,756 40. 424 00:22:16,844 --> 00:22:18,138 So we can test 425 00:22:18,225 --> 00:22:20,933 all of the possible medications for... 426 00:22:21,297 --> 00:22:22,768 Are you throwing a party? 427 00:22:23,073 --> 00:22:24,241 Hope so. 428 00:22:36,827 --> 00:22:38,688 How are you doing, Shaun? 429 00:22:39,409 --> 00:22:41,297 Since your father passed away? 430 00:22:43,326 --> 00:22:47,555 I don't think about him very much. 431 00:22:51,884 --> 00:22:55,102 My mom... died recently. 432 00:22:55,539 --> 00:22:57,117 I‐I don't know if you knew that. 433 00:22:58,549 --> 00:23:01,672 She pops into my head all the time. 434 00:23:03,020 --> 00:23:04,852 Not always the nicest thoughts. 435 00:23:11,770 --> 00:23:15,680 It's okay not to love them. 436 00:23:17,284 --> 00:23:19,241 They didn't make us who we are. 437 00:23:56,115 --> 00:23:58,016 Has your mom gone home? 438 00:24:00,244 --> 00:24:03,820 There is one more thing we have to deal with tonight. 439 00:24:05,360 --> 00:24:06,455 Come on. 440 00:24:06,542 --> 00:24:09,383 How many more sets of imaging can you possibly do? 441 00:24:10,778 --> 00:24:13,503 One of these is your prom dress. 442 00:24:13,899 --> 00:24:17,591 I like the pink, but I think you'd look gorgeous in both. 443 00:24:21,432 --> 00:24:22,805 Hurry up and choose. 444 00:24:22,892 --> 00:24:24,680 Your date'll be here soon. 445 00:24:37,782 --> 00:24:40,239 All the medications are in. 446 00:24:40,451 --> 00:24:44,410 Which means more waiting to see which medicine works. 447 00:24:44,497 --> 00:24:46,290 It's hard to be patient. 448 00:24:51,587 --> 00:24:55,610 Do you think the fish control how they react to the meds? 449 00:24:55,985 --> 00:24:57,695 No. 450 00:24:58,052 --> 00:25:00,742 It's just how their bodies respond. 451 00:25:03,411 --> 00:25:05,469 That's how I felt last night. 452 00:25:07,847 --> 00:25:11,492 I thought I was ready for us to be together, but... 453 00:25:12,145 --> 00:25:14,731 my body had a different response. 454 00:25:16,487 --> 00:25:18,303 I can't turn that response off 455 00:25:18,391 --> 00:25:20,217 any more than these fish can control 456 00:25:20,305 --> 00:25:22,781 how their mutation reacts to the medication. 457 00:25:29,329 --> 00:25:34,719 Was our mutation me going to Wyoming with Lea? 458 00:25:41,125 --> 00:25:45,304 Do you think we can find our right medication? 459 00:25:58,516 --> 00:26:01,445 ♪ I found a love ♪ 460 00:26:01,774 --> 00:26:03,989 ♪ For me ♪ 461 00:26:06,156 --> 00:26:09,703 ♪ Darling, just dive right in ♪ 462 00:26:09,945 --> 00:26:11,830 ♪ Follow my lead ♪ 463 00:26:13,690 --> 00:26:17,106 ♪ I found a girl ♪ 464 00:26:17,339 --> 00:26:19,391 ♪ Beautiful and sweet ♪ 465 00:26:19,479 --> 00:26:21,186 You look amazing. 466 00:26:21,274 --> 00:26:25,858 ♪ I never knew you were the someone waiting for me ♪ 467 00:26:26,098 --> 00:26:27,680 So do you. 468 00:26:27,768 --> 00:26:32,269 ♪ 'Cause we were just kids when we fell in love ♪ 469 00:26:32,563 --> 00:26:36,355 ♪ Not knowing what it was ♪ 470 00:26:36,442 --> 00:26:43,904 ♪ I will not give you up this time ♪ 471 00:26:43,991 --> 00:26:47,574 ♪ Darling, just kiss me slow ♪ 472 00:26:47,820 --> 00:26:51,411 ♪ Your heart is all I own ♪ 473 00:26:51,641 --> 00:26:58,126 ♪ And in your eyes, you're holding mine ♪ 474 00:26:58,213 --> 00:27:05,384 ♪ Baby, I'm dancing in the dark ♪ 475 00:27:05,750 --> 00:27:09,429 ♪ With you between my arms ♪ 476 00:27:09,563 --> 00:27:13,183 ♪ Barefoot on the grass ♪ 477 00:27:13,391 --> 00:27:16,603 ♪ Listening to our favorite song ♪ 478 00:27:16,690 --> 00:27:20,107 ♪ When you said you looked a mess ♪ 479 00:27:20,194 --> 00:27:23,522 ♪ I whispered underneath my breath ♪ 480 00:27:23,610 --> 00:27:24,982 Looks like you might be feeling 481 00:27:25,070 --> 00:27:27,406 a little idiotic happiness right now. 482 00:27:27,695 --> 00:27:29,149 Mm... 483 00:27:29,453 --> 00:27:31,110 maybe a touch. 484 00:27:36,377 --> 00:27:38,045 ♪ No, no ♪ 485 00:27:38,133 --> 00:27:40,002 Dance with a prom king? 486 00:27:40,089 --> 00:27:41,962 Ohh. 487 00:27:42,049 --> 00:27:45,235 ♪ You look perfect tonight ♪ 488 00:27:58,767 --> 00:28:00,672 He's tachycardic. 489 00:28:02,029 --> 00:28:03,781 We were talking, and then he just stopped. 490 00:28:03,869 --> 00:28:05,266 We need to do a pericardial tap. 491 00:28:05,354 --> 00:28:07,061 Call the cath lab. Tell them we're coming. 492 00:28:07,149 --> 00:28:08,404 No time. We're doing it here. 493 00:28:08,492 --> 00:28:09,795 James, the pain in your chest 494 00:28:09,883 --> 00:28:11,413 is from too much fluid around your heart. 495 00:28:11,500 --> 00:28:13,189 We're gonna put a tube into your chest to drain it. 496 00:28:13,276 --> 00:28:15,557 Call Shaun and Carly. Tell them we're running out of time. 497 00:28:18,085 --> 00:28:24,004 ♪ ...will be loving you till we're 70 ♪ 498 00:28:28,947 --> 00:28:36,947 ♪ And, baby, my heart could still fall as hard at 23 ♪ 499 00:28:39,461 --> 00:28:42,230 ♪ And I'm thinking about how ♪ 500 00:28:42,317 --> 00:28:46,719 ♪ People fall in love in mysterious ways ♪ 501 00:28:46,834 --> 00:28:48,611 I brought Angie's Bearfeet Bear. 502 00:28:48,745 --> 00:28:50,289 It always makes her feel like sh... 503 00:28:54,246 --> 00:28:56,547 It's... prom. 504 00:28:56,957 --> 00:28:59,352 Ryan has been wearing his mask all night. 505 00:29:00,294 --> 00:29:04,878 ♪ And I just want to tell you I am ♪ 506 00:29:04,965 --> 00:29:07,631 ♪ So, honey, now ♪ 507 00:29:10,637 --> 00:29:14,596 ♪ Take me into your loving arms ♪ 508 00:29:14,683 --> 00:29:16,360 Don't let her stay up too late. 509 00:29:16,685 --> 00:29:20,936 ♪ Kiss me under the light of a thousand stars ♪ 510 00:29:22,691 --> 00:29:25,273 ♪ Place your hand on my beating heart ♪ 511 00:29:31,617 --> 00:29:34,719 Morgan called. James isn't doing well. 512 00:29:40,501 --> 00:29:43,633 Cross SL‐327 off the list. 513 00:29:44,463 --> 00:29:46,438 I see one... 514 00:29:46,584 --> 00:29:49,891 no, two tumors. 515 00:30:11,794 --> 00:30:13,008 Okay. 516 00:30:13,382 --> 00:30:14,969 This is my stop. 517 00:30:15,057 --> 00:30:16,555 I'll see you after. 518 00:30:16,891 --> 00:30:18,326 I love you. 519 00:30:18,500 --> 00:30:20,531 I love you, too, Mom. 520 00:30:23,358 --> 00:30:25,414 Don't worry. Okay? 521 00:30:25,873 --> 00:30:27,624 I got this. 522 00:30:29,633 --> 00:30:31,070 I know you do. 523 00:30:39,211 --> 00:30:40,240 Okay. 524 00:30:40,328 --> 00:30:41,467 Okay. 525 00:30:46,715 --> 00:30:51,344 What if I wake up and don't remember Ryan at all? 526 00:30:54,584 --> 00:30:56,507 Then... 527 00:30:57,039 --> 00:30:58,858 you'll have the chance to fall in love with him 528 00:30:58,945 --> 00:31:00,368 all over again. 529 00:31:04,501 --> 00:31:05,914 Okay. 530 00:31:07,011 --> 00:31:08,011 Okay. 531 00:31:19,224 --> 00:31:21,515 We're down to five potential options. 532 00:31:21,602 --> 00:31:23,850 I don't need five potential. I need one actual. 533 00:31:23,937 --> 00:31:25,707 There are two that best curb... 534 00:31:25,795 --> 00:31:26,838 Choose one. 535 00:31:27,858 --> 00:31:31,498 We should try Refametinib. 536 00:31:31,586 --> 00:31:33,404 It caused abnormal cell growth. 537 00:31:33,492 --> 00:31:35,195 Trametinib is safer. 538 00:31:35,695 --> 00:31:37,201 Which doesn't mean it's safe. 539 00:31:37,289 --> 00:31:38,360 Nothing's safe. 540 00:31:38,448 --> 00:31:39,616 Which do you want us to do? 541 00:31:44,607 --> 00:31:45,817 Trametinib. 542 00:31:45,905 --> 00:31:46,914 That's the one. 543 00:31:52,750 --> 00:31:54,090 Saline in. 544 00:31:54,301 --> 00:31:56,758 Advancing scope toward the third ventricle. 545 00:31:56,845 --> 00:31:58,854 Claire, hold gentle pressure on the tumor 546 00:31:58,942 --> 00:32:00,804 while I cut off its blood supply. 547 00:32:07,452 --> 00:32:09,131 We've got some significant bleeding. 548 00:32:09,219 --> 00:32:10,901 Adjust the scope and suction. 549 00:32:15,765 --> 00:32:17,200 Look higher. 550 00:32:17,875 --> 00:32:19,797 Septal vein... there's your bleeder. 551 00:32:19,885 --> 00:32:21,095 Cauterize away. 552 00:33:06,208 --> 00:33:07,535 Micro dissector. 553 00:33:12,713 --> 00:33:14,098 The tumor's immobile. 554 00:33:14,473 --> 00:33:16,635 I can't resect it without injuring the nerve tracts. 555 00:33:16,723 --> 00:33:18,247 She'd be comatose. 556 00:33:18,353 --> 00:33:19,688 Try sharp dissection. 557 00:33:21,413 --> 00:33:22,995 I can't get a plane. How bad? 558 00:33:23,114 --> 00:33:24,971 It's completely invaded her thalamus. 559 00:33:25,223 --> 00:33:28,778 Thin it out with a suction aspirator. 560 00:33:34,606 --> 00:33:35,982 It's too adherent. 561 00:33:36,200 --> 00:33:38,071 If I keep going, I'm gonna kill her. 562 00:33:40,099 --> 00:33:41,600 Any ideas? 563 00:34:03,258 --> 00:34:06,761 Tell ICU Angie will be coming sooner than we planned. 564 00:34:08,533 --> 00:34:10,031 Let's close her up. 565 00:34:28,526 --> 00:34:29,982 What's next? 566 00:34:30,217 --> 00:34:32,231 Another round of radiation, chemo? 567 00:34:35,253 --> 00:34:37,880 Her carcinoma is... 568 00:34:37,968 --> 00:34:40,471 unlikely to respond to those therapies. 569 00:34:44,304 --> 00:34:45,411 No. 570 00:34:45,499 --> 00:34:47,455 We have to try. 571 00:34:47,682 --> 00:34:49,014 Angie will want to fight. 572 00:34:49,101 --> 00:34:50,339 She's seizing. 573 00:34:50,426 --> 00:34:51,683 Give me lorazepam and Dilantin, stat. 574 00:34:51,770 --> 00:34:53,239 Phenobarb and propofol on deck. 575 00:35:15,947 --> 00:35:17,411 You're crying. 576 00:35:20,783 --> 00:35:21,909 Yes. 577 00:35:25,470 --> 00:35:26,888 Why? 578 00:35:29,307 --> 00:35:31,419 I found James on Facebook. 579 00:35:33,437 --> 00:35:36,106 He and Marjorie want to go to Costa Rica. 580 00:35:37,818 --> 00:35:41,193 Their dog is a three‐legged rescue named Tripod. 581 00:35:46,020 --> 00:35:48,528 He's not a slide. He's a person. 582 00:35:49,536 --> 00:35:51,073 He's a good person. 583 00:35:51,161 --> 00:35:52,528 And he might die. 584 00:35:54,450 --> 00:35:56,840 This is why I like to stay in the lab. 585 00:36:02,215 --> 00:36:03,887 That... 586 00:36:04,384 --> 00:36:07,223 is a very dumb thing to say. 587 00:36:09,628 --> 00:36:11,856 If you had stayed in the lab, 588 00:36:12,350 --> 00:36:15,731 James would probably be dead already. 589 00:36:18,356 --> 00:36:23,387 Your plan with the zebrafish gave him a chance. 590 00:36:23,739 --> 00:36:28,528 It was a beautiful, perfect idea, 591 00:36:29,551 --> 00:36:32,667 from a beautiful, almost perfect person. 592 00:36:38,333 --> 00:36:40,786 Your earlobes are lopsided. 593 00:37:14,590 --> 00:37:16,434 I'm so sorry. 594 00:37:16,950 --> 00:37:18,621 We couldn't save her. 595 00:37:39,270 --> 00:37:40,684 Ms. Valens? 596 00:38:13,346 --> 00:38:15,426 Nice call on the zebrafish. 597 00:38:34,638 --> 00:38:36,845 About our paper, let's meet weekly. 598 00:38:36,933 --> 00:38:39,652 I'm thinking lunch every Tuesday in the cafeteria. 599 00:38:39,740 --> 00:38:40,866 Perfect. 600 00:38:51,045 --> 00:38:53,950 I heard about Melendez's patient. 601 00:38:57,030 --> 00:38:58,419 Yeah. 602 00:39:08,318 --> 00:39:09,692 You were right. 603 00:39:09,826 --> 00:39:14,106 I should probably try another medication for my RA. 604 00:39:15,796 --> 00:39:17,631 I need solid food. 605 00:39:29,250 --> 00:39:31,215 Melendez: Claire? Wait up. 606 00:39:32,258 --> 00:39:33,598 You okay? 607 00:39:33,944 --> 00:39:36,030 Fine. I'm just tired. 608 00:39:37,931 --> 00:39:40,054 You did an amazing thing for Angie. 609 00:39:40,141 --> 00:39:42,724 You gave her mother a memory that she will have forever. 610 00:39:43,121 --> 00:39:45,481 Well, it won't make up for the daughter she lost. 611 00:39:45,863 --> 00:39:47,143 You're angry. 612 00:39:47,231 --> 00:39:49,314 I'm not. I am sad. 613 00:39:49,401 --> 00:39:51,274 - Who are you angry at? - I'm not. 614 00:39:51,361 --> 00:39:53,610 Are you angry at me and Glassman because we couldn't save her? 615 00:39:53,697 --> 00:39:55,194 - No! - At Angie? 616 00:39:55,281 --> 00:39:58,301 No, you can't be mad at someone for dying! 617 00:39:59,066 --> 00:40:01,147 That's not true. You know that. 618 00:40:03,367 --> 00:40:05,044 She was sick. 619 00:40:05,161 --> 00:40:07,332 And she was trying to get better. 620 00:40:07,419 --> 00:40:09,489 She failed and left you alone. 621 00:40:09,701 --> 00:40:12,801 After you'd spent a lifetime trying to take care of her. 622 00:40:13,273 --> 00:40:15,637 You have every reason to be mad at your mother. 623 00:40:16,821 --> 00:40:18,567 I hate feeling this way. 624 00:40:18,737 --> 00:40:20,718 My whole life, I've been angry at her, 625 00:40:20,806 --> 00:40:22,989 and now it will never change. 626 00:40:23,702 --> 00:40:25,528 I don't know how to stop. 627 00:40:29,278 --> 00:40:31,438 Therapy will help. 628 00:40:31,786 --> 00:40:33,278 Time will help. 629 00:40:35,154 --> 00:40:37,819 There is one other thing that's worked for me. 630 00:40:50,122 --> 00:40:52,502 Did we fix our mutation? 631 00:41:05,762 --> 00:41:07,308 That the best you got?